Short-duration preoperative endocrine therapy alters molecular profiles to predict favourable outcome in ER+/HER2+ early breast cancer: a POETIC translational studyResearch in context

Short-duration preoperative endocrine therapy alters molecular profiles to predict favourable outcome in ER+/HER2+ early breast cancer: a POETIC translational studyResearch in context

Summary: Background: About 15–20% of breast cancers (BC) overexpress Human Epidermal Growth Factor Receptor 2 (HER2+), and 50% of them are also oestrogen receptor positive (ER+). Patients with ER+/HER2+ BC with a limited response to systemic therapies are at an increased risk of relapse, thus under...

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Bibliographic Details
Main Authors: Milana Bergamino Sirvén, Elena López-Knowles, Xixuan Zhu, Holly Tovey, Lucy Kilburn, Chris Holcombe, Anthony Skene, John Robertson, Judith M. Bliss, Anastasia Alataki, Ian Smith, Eugene F. Schuster, Mitch Dowsett, Maggie Chon U. Cheang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Breast cancer
HER2+
Aromatase inhibitors
Intrinsic subtypes
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002671
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