Efficacy of Remineralizing Agents for Prevention of Microhardness Reduction and Change in Mineral Content of Enamel in Anterior Primary Teeth after Exposure to Iron Drop
Background: Some alterations in the enamel structure of primary teeth have been reported following iron drop consumption. The efficacy of different remineralizing agents for this problem is still challenging.Purpose: This study aimed to assess the efficacy of remineralizing agents for prevention of...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2025-06-01
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| Series: | Journal of Dentistry |
| Subjects: | |
| Online Access: | https://dentjods.sums.ac.ir/article_50259_c8fde099cf42f77f5229ab233ea3bfcf.pdf |
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| Summary: | Background: Some alterations in the enamel structure of primary teeth have been reported following iron drop consumption. The efficacy of different remineralizing agents for this problem is still challenging.Purpose: This study aimed to assess the efficacy of remineralizing agents for prevention of microhardness reduction and change in primary enamel mineral content after exposure to iron drop.Materials and Method: In this experimental study, 36 sound primary anterior teeth were assigned to four groups of control, casein phosphopeptide amorphous calcium phosphate (CPP-ACP), fluoride varnish (FV), and CPP-ACP+FV (MI varnish). The baseline microhardness of the teeth was first measured by Vickers hardness tester using 50 g load for 10 seconds. Next, the microhardness was measured after remineralizing agents were applied on the specimens. After the application of iron drop for 5 minutes, and pH cycling for 10 days, the final microhardness of specimens was registered. Specimens were also subjected to energy dispersive X-ray spectroscopy (EDS) in the control group, after remineralization and after the application of iron drop. Data were analyzed by one-way ANOVA, Tukey’s test, and Tamhane’s test.Results: The final microhardness was significantly higher in all remineralized groups compared to the control group (p Value= 0.003). The final microhardness was significantly hig-her in MI varnish compared to FV (p= 0.027), CPP-ACP (p= 0.03), and control (p< 0.0001) groups. According to EDS, calcium (Ca) and ferric (Fe) content were significantly different between the remineralizing groups and control groups in the final step (p< 0.00001).Conclusion: Application of CPP-ACP, FV, and MI varnish prior to iron drop exposure can improve microhardness. MI varnish had significantly higher efficacy for this purpose than the other two remineralizing agents. |
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| ISSN: | 2345-6485 2345-6418 |