Distal renal denervation: cardioprotection in patients with resistant hypertension
Aim. To study the effectiveness of using the anatomically optimized distal renal denervation (RDN) in comparison with the standard approach for reducing myocardial damage and left ventricular (LV) hypertrophy in patients with resistant hypertension (HTN).Material and methods. The randomized double-b...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2020-09-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2225 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849408605033332736 |
|---|---|
| author | E. S. Sitkova V. F. Mordovin S. E. Pekarsky T. M. Ripp A. Yu. Falkovskaya V. A. Lichikaki I. V. Zyubanova A. E. Baev T. R. Ryabova O. V. Mochula V. Yu. Usov |
| author_facet | E. S. Sitkova V. F. Mordovin S. E. Pekarsky T. M. Ripp A. Yu. Falkovskaya V. A. Lichikaki I. V. Zyubanova A. E. Baev T. R. Ryabova O. V. Mochula V. Yu. Usov |
| author_sort | E. S. Sitkova |
| collection | DOAJ |
| description | Aim. To study the effectiveness of using the anatomically optimized distal renal denervation (RDN) in comparison with the standard approach for reducing myocardial damage and left ventricular (LV) hypertrophy in patients with resistant hypertension (HTN).Material and methods. The randomized double-blind study of the efficacy and safety of distal RDN compared to conventional main renal artery intervention (ClinicalTrials.gov NCT02667912) for the treatment of resistant HTN included 26 patients. All patients were divided into two groups: group 1 (n=16) — distal RDN, group 2 (n=10) — conventional RDN. In addition to 24-hour blood pressure (BP) monitoring, initially and 12 months after the intervention, contrast- enhanced cardiac magnetic resonance imaging was performed to determine the left ventricular mass and non-coronary myocardial damage area. All patients signed informed consent. Twenty-four patients completed the present study.Results. After 12 months, the mean 24-hour BP significantly decreased after both distal RDN (from 167,2±28,5/93,2±19,3 to 147,0±13,7/81,5±9,3 mm Hg (p<0,05)) and conventional RDN (from 157,5±22,5/90,6±23,9 to 139,9±17,7/80,0±16,7 (p<0,05)). Also in both cases, a trend to LV mass decrease was revealed: from 252,6±85,2 to 221,0±60,3 gm (p=0,096) after the distal RDN; from 214,3±54,1 to 186,4±48,1 gm (p=0,071) after the conventional RDN. In contrast, the myocardial damage area decreased only after distal RDN (from 2,33±1,33 to 1,35±0,67 cm3 (p=0,02)) and did not change after conventional RDN.Conclusion. In comparison with the conventional main renal artery intervention, distal RDN in patients with resistant HTN has an additional cardioprotective effect — a decrease in LV myocardial damage area. |
| format | Article |
| id | doaj-art-88d878f0d08d42e9a0809d7d635da313 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-88d878f0d08d42e9a0809d7d635da3132025-08-20T03:35:44Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252020-09-0119410.15829/1728-8800-2019-22252163Distal renal denervation: cardioprotection in patients with resistant hypertensionE. S. Sitkova0V. F. Mordovin1S. E. Pekarsky2T. M. Ripp3A. Yu. Falkovskaya4V. A. Lichikaki5I. V. Zyubanova6A. E. Baev7T. R. Ryabova8O. V. Mochula9V. Yu. Usov10Cardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterAim. To study the effectiveness of using the anatomically optimized distal renal denervation (RDN) in comparison with the standard approach for reducing myocardial damage and left ventricular (LV) hypertrophy in patients with resistant hypertension (HTN).Material and methods. The randomized double-blind study of the efficacy and safety of distal RDN compared to conventional main renal artery intervention (ClinicalTrials.gov NCT02667912) for the treatment of resistant HTN included 26 patients. All patients were divided into two groups: group 1 (n=16) — distal RDN, group 2 (n=10) — conventional RDN. In addition to 24-hour blood pressure (BP) monitoring, initially and 12 months after the intervention, contrast- enhanced cardiac magnetic resonance imaging was performed to determine the left ventricular mass and non-coronary myocardial damage area. All patients signed informed consent. Twenty-four patients completed the present study.Results. After 12 months, the mean 24-hour BP significantly decreased after both distal RDN (from 167,2±28,5/93,2±19,3 to 147,0±13,7/81,5±9,3 mm Hg (p<0,05)) and conventional RDN (from 157,5±22,5/90,6±23,9 to 139,9±17,7/80,0±16,7 (p<0,05)). Also in both cases, a trend to LV mass decrease was revealed: from 252,6±85,2 to 221,0±60,3 gm (p=0,096) after the distal RDN; from 214,3±54,1 to 186,4±48,1 gm (p=0,071) after the conventional RDN. In contrast, the myocardial damage area decreased only after distal RDN (from 2,33±1,33 to 1,35±0,67 cm3 (p=0,02)) and did not change after conventional RDN.Conclusion. In comparison with the conventional main renal artery intervention, distal RDN in patients with resistant HTN has an additional cardioprotective effect — a decrease in LV myocardial damage area.https://cardiovascular.elpub.ru/jour/article/view/2225resistant hypertensionmyocardial damageleft ventricular hypertrophydistal renal denervationregression |
| spellingShingle | E. S. Sitkova V. F. Mordovin S. E. Pekarsky T. M. Ripp A. Yu. Falkovskaya V. A. Lichikaki I. V. Zyubanova A. E. Baev T. R. Ryabova O. V. Mochula V. Yu. Usov Distal renal denervation: cardioprotection in patients with resistant hypertension Кардиоваскулярная терапия и профилактика resistant hypertension myocardial damage left ventricular hypertrophy distal renal denervation regression |
| title | Distal renal denervation: cardioprotection in patients with resistant hypertension |
| title_full | Distal renal denervation: cardioprotection in patients with resistant hypertension |
| title_fullStr | Distal renal denervation: cardioprotection in patients with resistant hypertension |
| title_full_unstemmed | Distal renal denervation: cardioprotection in patients with resistant hypertension |
| title_short | Distal renal denervation: cardioprotection in patients with resistant hypertension |
| title_sort | distal renal denervation cardioprotection in patients with resistant hypertension |
| topic | resistant hypertension myocardial damage left ventricular hypertrophy distal renal denervation regression |
| url | https://cardiovascular.elpub.ru/jour/article/view/2225 |
| work_keys_str_mv | AT essitkova distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT vfmordovin distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT sepekarsky distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT tmripp distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT ayufalkovskaya distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT valichikaki distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT ivzyubanova distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT aebaev distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT trryabova distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT ovmochula distalrenaldenervationcardioprotectioninpatientswithresistanthypertension AT vyuusov distalrenaldenervationcardioprotectioninpatientswithresistanthypertension |