Key shifts in frontoparietal network activity in Parkinson’s disease
Abstract We aimed to study the effect of Parkinson’s disease (PD) and motor-cognitive load on the interplay between activation level and spatial complexity. To that end, 68 PD patients and 30 controls underwent electroencephalography (EEG) recording while executing visual single- and dual- Go/No-go...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00866-0 |
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| author | Ronen Sosnik Firas Fahoum Zoya Katzir Anat Mirelman Inbal Maidan |
| author_facet | Ronen Sosnik Firas Fahoum Zoya Katzir Anat Mirelman Inbal Maidan |
| author_sort | Ronen Sosnik |
| collection | DOAJ |
| description | Abstract We aimed to study the effect of Parkinson’s disease (PD) and motor-cognitive load on the interplay between activation level and spatial complexity. To that end, 68 PD patients and 30 controls underwent electroencephalography (EEG) recording while executing visual single- and dual- Go/No-go tasks. The EEG underwent source localization, followed by parcellation of the neural activity into 116 regions of interest. We observed alterations in activity within a distributed network of brain areas associated with attention and inhibition operations, including a circuit pathway connecting frontal and temporal/parietal regions and the limbic network. The alterations in activity were associated with task complexity (single- or dual- task) and group (PD or controls) and encompassed spatial, temporal and spectral dimensions. These results elucidate electrophysiological alterations in four core aspects of brain activity associated with motor-cognitive function in PD patients and hold potential implications for future studies involving adaptive electrical interventions. |
| format | Article |
| id | doaj-art-88cebd4e3e994c5299d5a2a82b767a80 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-88cebd4e3e994c5299d5a2a82b767a802025-01-05T12:12:06ZengNature Portfolionpj Parkinson's Disease2373-80572025-01-0111111010.1038/s41531-024-00866-0Key shifts in frontoparietal network activity in Parkinson’s diseaseRonen Sosnik0Firas Fahoum1Zoya Katzir2Anat Mirelman3Inbal Maidan4Faculty of Electrical Engineering, Holon Institute of Technology (H.I.T.)Brain Electrophysiology and Epilepsy Lab (BEE-L), Epilepsy and EEG Unit, Neurological Institute, Tel Aviv Sourasky Medical CenterDepartment of Neurology, School of Medicine, Tel Aviv UniversityDepartment of Neurology, School of Medicine, Tel Aviv UniversityBrain Electrophysiology and Epilepsy Lab (BEE-L), Epilepsy and EEG Unit, Neurological Institute, Tel Aviv Sourasky Medical CenterAbstract We aimed to study the effect of Parkinson’s disease (PD) and motor-cognitive load on the interplay between activation level and spatial complexity. To that end, 68 PD patients and 30 controls underwent electroencephalography (EEG) recording while executing visual single- and dual- Go/No-go tasks. The EEG underwent source localization, followed by parcellation of the neural activity into 116 regions of interest. We observed alterations in activity within a distributed network of brain areas associated with attention and inhibition operations, including a circuit pathway connecting frontal and temporal/parietal regions and the limbic network. The alterations in activity were associated with task complexity (single- or dual- task) and group (PD or controls) and encompassed spatial, temporal and spectral dimensions. These results elucidate electrophysiological alterations in four core aspects of brain activity associated with motor-cognitive function in PD patients and hold potential implications for future studies involving adaptive electrical interventions.https://doi.org/10.1038/s41531-024-00866-0 |
| spellingShingle | Ronen Sosnik Firas Fahoum Zoya Katzir Anat Mirelman Inbal Maidan Key shifts in frontoparietal network activity in Parkinson’s disease npj Parkinson's Disease |
| title | Key shifts in frontoparietal network activity in Parkinson’s disease |
| title_full | Key shifts in frontoparietal network activity in Parkinson’s disease |
| title_fullStr | Key shifts in frontoparietal network activity in Parkinson’s disease |
| title_full_unstemmed | Key shifts in frontoparietal network activity in Parkinson’s disease |
| title_short | Key shifts in frontoparietal network activity in Parkinson’s disease |
| title_sort | key shifts in frontoparietal network activity in parkinson s disease |
| url | https://doi.org/10.1038/s41531-024-00866-0 |
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