Development of anti-fouling endoscope tip hood for gastrointestinal endoscopy
Abstract The contamination of the endoscope tip lens results in poor endoscopic imaging. To prevent the adsorption of contaminants, we applied a soft contact lens made of 2-hydroxyethyl methacrylate hydrogel to the tip of a gastrointestinal endoscope. Additionally, a novel endoscopic hood with an up...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-92118-1 |
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| Summary: | Abstract The contamination of the endoscope tip lens results in poor endoscopic imaging. To prevent the adsorption of contaminants, we applied a soft contact lens made of 2-hydroxyethyl methacrylate hydrogel to the tip of a gastrointestinal endoscope. Additionally, a novel endoscopic hood with an upper surface composed of a single layer inside the hood cavity was developed. For in vitro anti-fouling performance testing using blood, changes in light transmittance were examined with hydrogel plates and compared to conventional quartz glass and surfactant-coated glass. The transmittance changes at a wavelength of 415 nm were 1.5% for the hydrogel plate, significantly lower than 82.9% for quartz glass and 85.2% for surfactant-coated glass (p < 0.001), demonstrating the hydrogel’s high anti-fouling performance. Another in vitro quantitative assay, evaluated by exposure to blood, lipid, and mucin liquids, showed high anti-fouling performance in the order hydrogel plate > surfactant-coated glass > quartz glass. Moreover, an in vivo pig model performing gastric endoscopic submucosal dissection was used to evaluate anti-fouling performance by analyzing endoscopic images with Michelson contrast. The contrast value of the upper surface group (Hydrogel) was 0.97, significantly higher than 0.62 for the non-upper surface group (Surfactant) (P < 0.001). Therefore, the novel anti-fouling endoscope tip hood could be applied in future clinical applications. |
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| ISSN: | 2045-2322 |