The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas
Introduction: Determining the relationship between TP53 gene mutation and treatment outcome in high-grade gliomas patients has great significance for disease prognosis and treatment outcome monitoring. Ojectives: To determine the relationship between TP53 gene mutation rate and some characteristic...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
ECIMED
2024-05-01
|
| Series: | Revista Cubana de Medicina Militar |
| Subjects: | |
| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/35778 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction: Determining the relationship between TP53 gene mutation and treatment outcome in high-grade gliomas patients has great significance for disease prognosis and treatment outcome monitoring.
Ojectives: To determine the relationship between TP53 gene mutation rate and some characteristics of treatment outcome in high-grade gliomas patients.
Methods: The study was conducted by descriptive method, on 52 high-grade gliomas patients at Vietnam National Cancer Hospital, from January 2019 to December 2020. Based on statistics of clinical symptoms, paraclinical tests and post-operative monitoring results, it was evaluated the relationship between TP53 gene mutation in study patients with response to treatment and patient's survival time.
Results: There was a relationship between TP53 gene mutation and response to treatment according to Response Evaluation Criteria In Solid Tumors (p= 0.004). Progression-free survival was higher in the group with the TP53 mutation than in the group without the TP53 mutation (χ2= 6.7; p= 0.010). The overall survival in the group with the TP53 mutation was higher than the overall survival in the group without the TP53 mutation (χ2= 2.6; p= 0.107).
Conclusion: There is a relationship between the occurrence of TP53 gene mutations with treatment response criteria and progression-free survival in patients with high-grade gliomas.
|
|---|---|
| ISSN: | 1561-3046 |