Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases
Background Small bowel injuries are rare in trauma. Diagnosing these injuries is difficult owing to the lack of clear signs, and delays in diagnosis might increase complications and mortality. Trauma can damage the vascular endothelial glycocalyx, with syndecan-1 emerging as a marker of injury. Here...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | Trauma Surgery & Acute Care Open |
| Online Access: | https://tsaco.bmj.com/content/10/1/e001727.full |
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| author | Hideshi Okada Keiko Suzuki Fuminori Yamaji Tetsuya Fukuta Masahiro Ichihashi Yosuke Mizuno Takahito Miyake Norihide Kanda |
| author_facet | Hideshi Okada Keiko Suzuki Fuminori Yamaji Tetsuya Fukuta Masahiro Ichihashi Yosuke Mizuno Takahito Miyake Norihide Kanda |
| author_sort | Hideshi Okada |
| collection | DOAJ |
| description | Background Small bowel injuries are rare in trauma. Diagnosing these injuries is difficult owing to the lack of clear signs, and delays in diagnosis might increase complications and mortality. Trauma can damage the vascular endothelial glycocalyx, with syndecan-1 emerging as a marker of injury. Here, we describe two cases of small bowel injury due to traffic motor vehicle crash trauma.Case presentation The patients, one in their 40s and one teenaged, were transported to our hospital after a traffic motor vehicle crash. Both patients were wearing seat belts at the time of the motor vehicle crash, and the car’s airbags deployed properly. Their vital signs were stable at admission, and non-operative treatment was selected. However, their abdominal pain did not improve, and based on posthospitalization CT reconstructive imaging, intra-abdominal hemorrhage was suspected. Surgery was performed, revealing small intestinal injuries. In both patients, a high serum syndecan-1 level in the blood test at admission was a common characteristic.Conclusion Increased serum syndecan-1 level was observed in blood tests during the initial treatment of small intestinal injuries in these patients, suggesting its potential utility in early diagnosis. However, further accumulation of cases and detailed studies are required to substantiate these results. |
| format | Article |
| id | doaj-art-88af8d65da6f4402a0f016350ee789df |
| institution | Kabale University |
| issn | 2397-5776 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Trauma Surgery & Acute Care Open |
| spelling | doaj-art-88af8d65da6f4402a0f016350ee789df2025-01-30T23:15:09ZengBMJ Publishing GroupTrauma Surgery & Acute Care Open2397-57762025-01-0110110.1136/tsaco-2024-001727Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two casesHideshi Okada0Keiko Suzuki1Fuminori Yamaji2Tetsuya Fukuta3Masahiro Ichihashi4Yosuke Mizuno5Takahito Miyake6Norihide Kanda7Department of Emergency and Disaster Medicine, Gifu University School of Medicine Graduate School of Medicine, Gifu, Gifu Prefecture, JapanGifu University Hospital, Gifu, JapanGifu University Hospital, Gifu, JapanDepartment of Emergency and Disaster Medicine, Gifu University School of Medicine Graduate School of Medicine, Gifu, Gifu Prefecture, JapanGifu University Hospital, Gifu, JapanGifu University Hospital, Gifu, JapanGifu University Hospital, Gifu, JapanGifu University Hospital, Gifu, JapanBackground Small bowel injuries are rare in trauma. Diagnosing these injuries is difficult owing to the lack of clear signs, and delays in diagnosis might increase complications and mortality. Trauma can damage the vascular endothelial glycocalyx, with syndecan-1 emerging as a marker of injury. Here, we describe two cases of small bowel injury due to traffic motor vehicle crash trauma.Case presentation The patients, one in their 40s and one teenaged, were transported to our hospital after a traffic motor vehicle crash. Both patients were wearing seat belts at the time of the motor vehicle crash, and the car’s airbags deployed properly. Their vital signs were stable at admission, and non-operative treatment was selected. However, their abdominal pain did not improve, and based on posthospitalization CT reconstructive imaging, intra-abdominal hemorrhage was suspected. Surgery was performed, revealing small intestinal injuries. In both patients, a high serum syndecan-1 level in the blood test at admission was a common characteristic.Conclusion Increased serum syndecan-1 level was observed in blood tests during the initial treatment of small intestinal injuries in these patients, suggesting its potential utility in early diagnosis. However, further accumulation of cases and detailed studies are required to substantiate these results.https://tsaco.bmj.com/content/10/1/e001727.full |
| spellingShingle | Hideshi Okada Keiko Suzuki Fuminori Yamaji Tetsuya Fukuta Masahiro Ichihashi Yosuke Mizuno Takahito Miyake Norihide Kanda Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases Trauma Surgery & Acute Care Open |
| title | Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases |
| title_full | Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases |
| title_fullStr | Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases |
| title_full_unstemmed | Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases |
| title_short | Effectiveness of syndecan-1 as an adjunct diagnostic marker in small bowel injury: a report of two cases |
| title_sort | effectiveness of syndecan 1 as an adjunct diagnostic marker in small bowel injury a report of two cases |
| url | https://tsaco.bmj.com/content/10/1/e001727.full |
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