Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor
Abstract Pyroptosis inducer, a powerful anti‐tumor agent that causes obvious programmed cell death and immune stimulation, has been challenged to trigger specific pyroptotic tumor cell death while keeping pyroptosis silence in normal cells. Here, an intelligent inducer is reported that acts as a rea...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202407713 |
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| author | Linlin Huo Shiqi Zhu Muyao Li Mingya Tan Mengke Fan Jiayi Zhao Jie Zeng Meiling Liu Kunyan Liu Chao Tong Zhenghuan Zhao |
| author_facet | Linlin Huo Shiqi Zhu Muyao Li Mingya Tan Mengke Fan Jiayi Zhao Jie Zeng Meiling Liu Kunyan Liu Chao Tong Zhenghuan Zhao |
| author_sort | Linlin Huo |
| collection | DOAJ |
| description | Abstract Pyroptosis inducer, a powerful anti‐tumor agent that causes obvious programmed cell death and immune stimulation, has been challenged to trigger specific pyroptotic tumor cell death while keeping pyroptosis silence in normal cells. Here, an intelligent inducer is reported that acts as a reactive oxygen species (ROS) scavenger in normal cells to keep pyroptosis silence, while serving as ROS generator to induce obvious pyroptotic tumor cells death dependent on high hydrogen peroxide levels and near‐infrared laser irradiation. This switchable activity ensures this inducer to precisely kill the tumor cells with augmented immunogenicity while causing minimal damage to normal cells. Moreover, the catalase‐like activity endows this inducer to overcome limitation of tumor hypoxia on ROS generation and show significant pyroptosis activation, further initiating the immune response to inhibit the tumor metastases in vivo. This study provides valuable insights into design new pyroptosis inducer with controllable pyroptosis activity to specifically induce programmed tumor cell pyroptosis for precise and augmented tumor therapy with minimal side effects. |
| format | Article |
| id | doaj-art-88af4121356b4c569825cf5419e77f53 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-88af4121356b4c569825cf5419e77f532025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202407713Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in TumorLinlin Huo0Shiqi Zhu1Muyao Li2Mingya Tan3Mengke Fan4Jiayi Zhao5Jie Zeng6Meiling Liu7Kunyan Liu8Chao Tong9Zhenghuan Zhao10College of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Life Sciences and Medicine Chengdu University of Traditional Chinese Medicine Chengdu 610075 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaNational Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing 401122 ChinaCollege of Basic Medical Sciences Chongqing Medical University Chongqing 400016 ChinaAbstract Pyroptosis inducer, a powerful anti‐tumor agent that causes obvious programmed cell death and immune stimulation, has been challenged to trigger specific pyroptotic tumor cell death while keeping pyroptosis silence in normal cells. Here, an intelligent inducer is reported that acts as a reactive oxygen species (ROS) scavenger in normal cells to keep pyroptosis silence, while serving as ROS generator to induce obvious pyroptotic tumor cells death dependent on high hydrogen peroxide levels and near‐infrared laser irradiation. This switchable activity ensures this inducer to precisely kill the tumor cells with augmented immunogenicity while causing minimal damage to normal cells. Moreover, the catalase‐like activity endows this inducer to overcome limitation of tumor hypoxia on ROS generation and show significant pyroptosis activation, further initiating the immune response to inhibit the tumor metastases in vivo. This study provides valuable insights into design new pyroptosis inducer with controllable pyroptosis activity to specifically induce programmed tumor cell pyroptosis for precise and augmented tumor therapy with minimal side effects.https://doi.org/10.1002/advs.202407713H2O2 responsiveprecise tumor therapyROS scavenger/generatorspecific pyroptosis |
| spellingShingle | Linlin Huo Shiqi Zhu Muyao Li Mingya Tan Mengke Fan Jiayi Zhao Jie Zeng Meiling Liu Kunyan Liu Chao Tong Zhenghuan Zhao Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor Advanced Science H2O2 responsive precise tumor therapy ROS scavenger/generator specific pyroptosis |
| title | Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor |
| title_full | Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor |
| title_fullStr | Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor |
| title_full_unstemmed | Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor |
| title_short | Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor |
| title_sort | intelligent pyroptosis inducer for precise and augmented tumor therapy through specific activation pyroptosis in tumor |
| topic | H2O2 responsive precise tumor therapy ROS scavenger/generator specific pyroptosis |
| url | https://doi.org/10.1002/advs.202407713 |
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