20:4-NAPE induced changes of mechanical sensitivity and DRG neurons excitability are concentration dependent and mediated via NAPE-PLD

20:4-NAPE induced changes of mechanical sensitivity and DRG neurons excitability are concentration dependent and mediated via NAPE-PLD

Abstract Alterations in the excitability of dorsal root ganglion (DRG) neurons are critical in the pathogenesis of acute and chronic pain. Neurotransmitter release from the terminals of DRG neurons is regulated by cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1), bot...

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Bibliographic Details
Main Authors: Anirban Bhattacharyya, Daniel Vasconcelos, Diana Spicarova, Jiri Palecek
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
20:4-NAPE
NAPE-PLD
Anandamide
CB1
TRPV1
DRG neurons
Online Access:https://doi.org/10.1038/s41598-025-98567-y
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