Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes

Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes

Background: There is an urgent need for pharmacological treatment for cocaine (COC) use disorder (CUD). Glutamatergic transmission in the prefrontal cortex is affected by addictive behaviors. Clavulanic acid (CLAV), a glutamate transporter GLT-1 (excitatory amino acid transporter) activator, is a cl...

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Bibliographic Details
Main Authors: Joya Maser, MS, Mary F. Morrison, MD, Helene Philogene Khalid, PhD, Ronan Cunningham, Daohai Yu, PhD, M. Ingre Walters, MD, Xiaoning Lu, Nicolas R. Bolo, PhD
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Therapeutic Research
Subjects:
anterior cingulate cortex
clavulanic acid
cocaine craving
cocaine use disorder
glutamate
resting state magnetic functional resonance imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X24000213
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