Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft)
Two new metal complexes of general formula M(Haαft)2 [M = NiII and CuII] of asymmetrical Schiff base ligand (HL = Haαft) derived from amoxicillin and α-formylthiophene have been prepared and characterized by various physicochemical and spectral techniques. Molar conductance measurement indicates non...
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/136285 |
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| author | Narendra Kumar Chaudhary Parashuram Mishra |
| author_facet | Narendra Kumar Chaudhary Parashuram Mishra |
| author_sort | Narendra Kumar Chaudhary |
| collection | DOAJ |
| description | Two new metal complexes of general formula M(Haαft)2 [M = NiII and CuII] of asymmetrical Schiff base ligand (HL = Haαft) derived from amoxicillin and α-formylthiophene have been prepared and characterized by various physicochemical and spectral techniques. Molar conductance measurement indicates nonelectrolytic nature of the metal complexes. FT-IR spectral study reveals the ligation of metal ions at two different nitrogen [NN] donor sites of Haαft. FT-IR and electronic absorption spectral evidences suggest distorted tetrahedral and square planar geometry for CuII and NiII complexes, respectively. The structure optimization by molecular mechanics (MM) force field calculation through ArgusLab 4.0.1 version software also supports the concerned geometry of the complexes. The cell dimensions as suggested by XRPD study, a (6.753 Å), b (13.904 Å), c (20.122 Å), α (142.76°), β (106.580°), and γ (72.4343°) for CuII and a (24.2547 Å), b (6.6371 Å), c (5.5047 Å) (α = β = γ = 90°) for NiII complexes, are in good agreement with their triclinic and orthorhombic crystal systems. Particle size calculation by Scherrer’s formula indicates nanocrystalline nature of the complexes. The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E. coli, P. vulgaris, P. aeruginosa, and S. aureus, though being less active than the standard drug amikacin. |
| format | Article |
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| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
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| series | Journal of Chemistry |
| spelling | doaj-art-889bf84ed0e84ee69ebb53b66dc6e1e22025-02-03T06:42:05ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/136285136285Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft)Narendra Kumar Chaudhary0Parashuram Mishra1Bio-Inorganic and Materials Chemistry Research Laboratory, Tribhuvan University, M.M.A.M. Campus, Biratnagar 56613, NepalBio-Inorganic and Materials Chemistry Research Laboratory, Tribhuvan University, M.M.A.M. Campus, Biratnagar 56613, NepalTwo new metal complexes of general formula M(Haαft)2 [M = NiII and CuII] of asymmetrical Schiff base ligand (HL = Haαft) derived from amoxicillin and α-formylthiophene have been prepared and characterized by various physicochemical and spectral techniques. Molar conductance measurement indicates nonelectrolytic nature of the metal complexes. FT-IR spectral study reveals the ligation of metal ions at two different nitrogen [NN] donor sites of Haαft. FT-IR and electronic absorption spectral evidences suggest distorted tetrahedral and square planar geometry for CuII and NiII complexes, respectively. The structure optimization by molecular mechanics (MM) force field calculation through ArgusLab 4.0.1 version software also supports the concerned geometry of the complexes. The cell dimensions as suggested by XRPD study, a (6.753 Å), b (13.904 Å), c (20.122 Å), α (142.76°), β (106.580°), and γ (72.4343°) for CuII and a (24.2547 Å), b (6.6371 Å), c (5.5047 Å) (α = β = γ = 90°) for NiII complexes, are in good agreement with their triclinic and orthorhombic crystal systems. Particle size calculation by Scherrer’s formula indicates nanocrystalline nature of the complexes. The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E. coli, P. vulgaris, P. aeruginosa, and S. aureus, though being less active than the standard drug amikacin.http://dx.doi.org/10.1155/2015/136285 |
| spellingShingle | Narendra Kumar Chaudhary Parashuram Mishra Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) Journal of Chemistry |
| title | Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) |
| title_full | Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) |
| title_fullStr | Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) |
| title_full_unstemmed | Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) |
| title_short | Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) |
| title_sort | spectral investigation and in vitro antibacterial evaluation of niii and cuii complexes of schiff base derived from amoxicillin and α formylthiophene αft |
| url | http://dx.doi.org/10.1155/2015/136285 |
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