Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms
Gestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over the past three decades. GDM adversely affects the maternal cardiovascular system, umbilical–placental blood perfusion, and fetal blood flow. We conduc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1474643/full |
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| author | Ze Zhang Yumeng Zhang Shuai Huang Min Li Lingjun Li Linglu Qi Yun He Zhice Xu Zhice Xu Jiaqi Tang |
| author_facet | Ze Zhang Yumeng Zhang Shuai Huang Min Li Lingjun Li Linglu Qi Yun He Zhice Xu Zhice Xu Jiaqi Tang |
| author_sort | Ze Zhang |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over the past three decades. GDM adversely affects the maternal cardiovascular system, umbilical–placental blood perfusion, and fetal blood flow. We conducted a comprehensive literature search and systematically evaluated and synthesized cardiovascular changes in the mothers, umbilical–placental circulation, and the progeny following exposure to GDM. Multiple pathophysiological mechanisms underlying cardiovascular alteration were investigated, including endothelial dysfunction, insulin resistance, oxidative stress, ion channel abnormalities, inflammation, angiogenic imbalance, and epigenetic modifications. These findings provide valuable insights for developing early intervention strategies and therapeutic approaches to mitigating cardiovascular risks in both mothers and offspring following GDM exposure. |
| format | Article |
| id | doaj-art-88953f14c190474fbf60dbdbce23dd08 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-88953f14c190474fbf60dbdbce23dd082025-08-20T02:31:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.14746431474643Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanismsZe Zhang0Yumeng Zhang1Shuai Huang2Min Li3Lingjun Li4Linglu Qi5Yun He6Zhice Xu7Zhice Xu8Jiaqi Tang9Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaUltrasound Department, The Fourth Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaObstetrical Department, Women’s Hospital School of Medicine Zhejiang University, Hangzhou, ChinaDepartment of Gynecology and Obstetrics, Taixing People’s Hospital, Taixing, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaResearch Institute for Reproductive Health and Genetic Diseases, Maternity and Child Health Care Hospital of Wuxi, Wuxi, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaGestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over the past three decades. GDM adversely affects the maternal cardiovascular system, umbilical–placental blood perfusion, and fetal blood flow. We conducted a comprehensive literature search and systematically evaluated and synthesized cardiovascular changes in the mothers, umbilical–placental circulation, and the progeny following exposure to GDM. Multiple pathophysiological mechanisms underlying cardiovascular alteration were investigated, including endothelial dysfunction, insulin resistance, oxidative stress, ion channel abnormalities, inflammation, angiogenic imbalance, and epigenetic modifications. These findings provide valuable insights for developing early intervention strategies and therapeutic approaches to mitigating cardiovascular risks in both mothers and offspring following GDM exposure.https://www.frontiersin.org/articles/10.3389/fendo.2025.1474643/fullcardiovascular systemgestational diabetes mellitusprogenyumbilical-placental circulationmother |
| spellingShingle | Ze Zhang Yumeng Zhang Shuai Huang Min Li Lingjun Li Linglu Qi Yun He Zhice Xu Zhice Xu Jiaqi Tang Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms Frontiers in Endocrinology cardiovascular system gestational diabetes mellitus progeny umbilical-placental circulation mother |
| title | Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms |
| title_full | Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms |
| title_fullStr | Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms |
| title_full_unstemmed | Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms |
| title_short | Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms |
| title_sort | influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms |
| topic | cardiovascular system gestational diabetes mellitus progeny umbilical-placental circulation mother |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1474643/full |
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