Targeted Overexpression of Mitochondrial ALDH2 in Coronary Endothelial Cells Mitigates HFpEF in a Diabetic Mouse Model

Heart failure (HF) has become an epidemic, with a prevalence of ~7 million cases in the USA. Despite accounting for nearly 50% of all HF cases, heart failure with a preserved ejection fraction (HFpEF) remains challenging to treat. Common pathophysiological mechanisms in HFpEF include oxidative stres...

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Bibliographic Details
Main Authors:	Guodong Pan, Bipradas Roy, Emmanuel Oppong Yeboah, Thomas Lanigan, Roland Hilgarth, Rajarajan A. Thandavarayan, Michael C. Petriello, Shailendra Giri, Suresh Selvaraj Palaniyandi
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Biomolecules
Subjects:	4-hydroxy-2-nonenal (4HNE) aldehyde dehydrogenase 2 (ALDH2) heart failure with preserved ejection fraction (HFpEF) coronary vascular endothelial cells (CVECs) gene transfer type 2 diabetes mellitus (T2DM)
Online Access:	https://www.mdpi.com/2218-273X/15/7/1029
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Targeted Overexpression of Mitochondrial ALDH2 in Coronary Endothelial Cells Mitigates HFpEF in a Diabetic Mouse Model

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