Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothel...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/474561 |
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| author | Andrea Scaramuzza Elisa Giani Francesca Redaelli Saverio Ungheri Maddalena Macedoni Valentina Giudici Alessandra Bosetti Matteo Ferrari Gian Vincenzo Zuccotti |
| author_facet | Andrea Scaramuzza Elisa Giani Francesca Redaelli Saverio Ungheri Maddalena Macedoni Valentina Giudici Alessandra Bosetti Matteo Ferrari Gian Vincenzo Zuccotti |
| author_sort | Andrea Scaramuzza |
| collection | DOAJ |
| description | After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction. Seventy-one children and adolescents, ages 17 ± 3.9 yrs, with type 1 diabetes since 9.5 ± 5.3 yrs, using intensified insulin therapy, were randomized into 3 arms: (a) antioxidant diet 10.000 ORAC + alpha-lipoic acid; (b) antioxidant diet 10.000 ORAC + placebo; (c) controls. BMI, blood pressure, fasting lipid profile, HbA1c, insulin requirement, dietary habits, and body composition were determined in each patient. An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid, unlike diet with placebo or controls. A significant reduction in bolus insulin was also observed. We speculate that alpha-lipoic acid might have an antioxidant effect in pediatric diabetes patients by reducing insulin. |
| format | Article |
| id | doaj-art-8893aa2f81e24207b5ef1edf48c4896a |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8893aa2f81e24207b5ef1edf48c4896a2025-08-20T03:38:06ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/474561474561Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot TrialAndrea Scaramuzza0Elisa Giani1Francesca Redaelli2Saverio Ungheri3Maddalena Macedoni4Valentina Giudici5Alessandra Bosetti6Matteo Ferrari7Gian Vincenzo Zuccotti8Pediatric Diabetology, Metabolic Diseases & Nutrition, Department of Pediatrics, Azienda Ospedaliera, University of Milano, “Ospedale Luigi Sacco”, 20157 Milan, ItalyDepartment of Pediatrics, University of Milano, “Ospedale dei Bambini Vittore Buzzi”, 20154 Milan, ItalyDepartment of Pediatrics, University of Milano, “Ospedale dei Bambini Vittore Buzzi”, 20154 Milan, ItalyDepartment of Pediatrics, University of Milano, “Ospedale dei Bambini Vittore Buzzi”, 20154 Milan, ItalyDepartment of Pediatrics, University of Milano, “Ospedale dei Bambini Vittore Buzzi”, 20154 Milan, ItalyDepartment of Pediatrics, University of Milano, “Ospedale dei Bambini Vittore Buzzi”, 20154 Milan, ItalyPediatric Diabetology, Metabolic Diseases & Nutrition, Department of Pediatrics, Azienda Ospedaliera, University of Milano, “Ospedale Luigi Sacco”, 20157 Milan, ItalyPediatric Diabetology, Metabolic Diseases & Nutrition, Department of Pediatrics, Azienda Ospedaliera, University of Milano, “Ospedale Luigi Sacco”, 20157 Milan, ItalyDepartment of Pediatrics, University of Milano, “Ospedale dei Bambini Vittore Buzzi”, 20154 Milan, ItalyAfter evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction. Seventy-one children and adolescents, ages 17 ± 3.9 yrs, with type 1 diabetes since 9.5 ± 5.3 yrs, using intensified insulin therapy, were randomized into 3 arms: (a) antioxidant diet 10.000 ORAC + alpha-lipoic acid; (b) antioxidant diet 10.000 ORAC + placebo; (c) controls. BMI, blood pressure, fasting lipid profile, HbA1c, insulin requirement, dietary habits, and body composition were determined in each patient. An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid, unlike diet with placebo or controls. A significant reduction in bolus insulin was also observed. We speculate that alpha-lipoic acid might have an antioxidant effect in pediatric diabetes patients by reducing insulin.http://dx.doi.org/10.1155/2015/474561 |
| spellingShingle | Andrea Scaramuzza Elisa Giani Francesca Redaelli Saverio Ungheri Maddalena Macedoni Valentina Giudici Alessandra Bosetti Matteo Ferrari Gian Vincenzo Zuccotti Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial Journal of Diabetes Research |
| title | Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial |
| title_full | Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial |
| title_fullStr | Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial |
| title_full_unstemmed | Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial |
| title_short | Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial |
| title_sort | alpha lipoic acid and antioxidant diet help to improve endothelial dysfunction in adolescents with type 1 diabetes a pilot trial |
| url | http://dx.doi.org/10.1155/2015/474561 |
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