Clonal divergence and genomic meltdown in prostatic pleomorphic giant cell adenocarcinoma

Clonal divergence and genomic meltdown in prostatic pleomorphic giant cell adenocarcinoma

BackgroundPleomorphic giant cell adenocarcinoma (PGCA) of the prostate is a rare, aggressive variant characterized by multinucleated giant cells, sarcomatoid features, and resistance to conventional therapies. Despite its recognition in the WHO 2016 guidelines, the molecular drivers and clinicopatho...

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Main Authors: Xiaoshi Ma, Kun Chen, Jing Zhang, Liming Liu, Jiping Luo, Kaipeng Huang, Hongying Zhang, Danni Liu, Jizhou Gou, Changyin Feng, Xia Zhao, Wanying Li, Lipeng Chen, Li Yin, Xianlin Meng, Zhiqiang Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
prostate cancer genomics
pleomorphic giant cell adenocarcinoma
divergent tumor evolution
cell cycle
apoptosis
therapeutic resistance biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609340/full
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