Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population
Aims. Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabetic osteoporosis has never been reported. This study is intended for studying th...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/9389720 |
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| author | Pijun Yan Yong Xu Zhihong Zhang Jianhua Zhu Ying Miao Chenlin Gao Qin Wan |
| author_facet | Pijun Yan Yong Xu Zhihong Zhang Jianhua Zhu Ying Miao Chenlin Gao Qin Wan |
| author_sort | Pijun Yan |
| collection | DOAJ |
| description | Aims. Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabetic osteoporosis has never been reported. This study is intended for studying the association between circulating omentin-1, bone mineral density (BMD), prior fragility fractures, and other bone metabolic-related parameters. Methods. Circulating omentin-1 levels were measured in 172 patients with type 2 diabetes mellitus (T2DM), and participants were divided into the normal BMD group (n=52), the osteopenia group (n=66), and the osteoporosis group (n=54). The relationship between circulating omentin-1 and diabetic osteoporosis and other parameters was analyzed. Results. Circulating omentin-1 was significantly higher in the osteoporosis group than in the normal group and in the osteopenia group (both P<0.05). Circulating omentin-1 levels were correlated significantly and positively with sex; high-density lipoprotein cholesterol; apolipoprotein A; and prevalence of prior fragility fractures, diabetic nephropathy, and retinopathy; they were correlated negatively with diastolic blood pressure, triglyceride, hemoglobin, atherogenic index of plasma, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites, and corresponding T scores, irrespective of age, sex, and body mass index (P<0.01 or P<0.05). Moreover, circulating omentin-1 was an independent decisive factor for the presence of osteoporosis only in women after multivariate adjustment (odds ratio: 1.069; 95% confidence interval: 1.003-1.139; P<0.05). Lastly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating omentin-1 to predict diabetic osteoporosis was 15.37 ng/mL (sensitivity: 71.7%; specificity: 58.5%) in female subjects. Conclusions. High levels of circulating omentin-1 may be associated with the development of osteoporosis in female diabetic subjects and may be a potential biomarker for diabetic osteoporosis in women. |
| format | Article |
| id | doaj-art-888e60a7a8e54afeb3a44c1a815cc0bb |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-888e60a7a8e54afeb3a44c1a815cc0bb2025-08-20T02:09:17ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/93897209389720Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic PopulationPijun Yan0Yong Xu1Zhihong Zhang2Jianhua Zhu3Ying Miao4Chenlin Gao5Qin Wan6Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of General Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaAims. Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabetic osteoporosis has never been reported. This study is intended for studying the association between circulating omentin-1, bone mineral density (BMD), prior fragility fractures, and other bone metabolic-related parameters. Methods. Circulating omentin-1 levels were measured in 172 patients with type 2 diabetes mellitus (T2DM), and participants were divided into the normal BMD group (n=52), the osteopenia group (n=66), and the osteoporosis group (n=54). The relationship between circulating omentin-1 and diabetic osteoporosis and other parameters was analyzed. Results. Circulating omentin-1 was significantly higher in the osteoporosis group than in the normal group and in the osteopenia group (both P<0.05). Circulating omentin-1 levels were correlated significantly and positively with sex; high-density lipoprotein cholesterol; apolipoprotein A; and prevalence of prior fragility fractures, diabetic nephropathy, and retinopathy; they were correlated negatively with diastolic blood pressure, triglyceride, hemoglobin, atherogenic index of plasma, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites, and corresponding T scores, irrespective of age, sex, and body mass index (P<0.01 or P<0.05). Moreover, circulating omentin-1 was an independent decisive factor for the presence of osteoporosis only in women after multivariate adjustment (odds ratio: 1.069; 95% confidence interval: 1.003-1.139; P<0.05). Lastly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating omentin-1 to predict diabetic osteoporosis was 15.37 ng/mL (sensitivity: 71.7%; specificity: 58.5%) in female subjects. Conclusions. High levels of circulating omentin-1 may be associated with the development of osteoporosis in female diabetic subjects and may be a potential biomarker for diabetic osteoporosis in women.http://dx.doi.org/10.1155/2020/9389720 |
| spellingShingle | Pijun Yan Yong Xu Zhihong Zhang Jianhua Zhu Ying Miao Chenlin Gao Qin Wan Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population Mediators of Inflammation |
| title | Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population |
| title_full | Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population |
| title_fullStr | Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population |
| title_full_unstemmed | Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population |
| title_short | Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population |
| title_sort | association of circulating omentin 1 with osteoporosis in a chinese type 2 diabetic population |
| url | http://dx.doi.org/10.1155/2020/9389720 |
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