Treatment of dilated cardiomyopathy with carvedilol in children
We performed a study to examine the clinical use of carvedilol, its dosage and its effects on systolic functions in children. Twenty-one patients with dilated cardiomyopathy who were treated with carvedilol adjacent to standard heart failure therapy were enrolled in the study. Echocardiograph...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2009-08-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2315 |
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| author | Ilkay Erdoğan Sema Ozer Tevfik Karagöz Alpay Celiker Süheyla Ozkutlu Dursun Alehan |
| author_facet | Ilkay Erdoğan Sema Ozer Tevfik Karagöz Alpay Celiker Süheyla Ozkutlu Dursun Alehan |
| author_sort | Ilkay Erdoğan |
| collection | DOAJ |
| description |
We performed a study to examine the clinical use of carvedilol, its dosage and its effects on systolic functions in children. Twenty-one patients with dilated cardiomyopathy who were treated with carvedilol adjacent to standard heart failure therapy were enrolled in the study. Echocardiographic assessment was obtained before and during carvedilol therapy, and left ventricular fractional shortening and left ventricular ejection fraction were determined in order to estimate left ventricular function. At a follow-up of six months, left ventricular ejection fraction and fractional shortening significantly improved from 38 +/- 10% to 53 +/- 13% and from 19 +/- 6 % to 27 +/- 8%, respectively, following carvedilol treatment. The results of the present study indicate that carvedilol is well tolerated in children with dilated cardiomyopathy and there is a significant improvement in the clinical status and left ventricular ejection fraction in patients not responding to conventional therapy. Patient selection criteria, optimal timing of carvedilol therapy, its dosage and its long-term effects need to be investigated with multi-institutional trials and large numbers of patients.
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| format | Article |
| id | doaj-art-887f4445e2f3423aa033bc22b6260f9e |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2009-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-887f4445e2f3423aa033bc22b6260f9e2025-08-20T02:55:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212009-08-01514Treatment of dilated cardiomyopathy with carvedilol in childrenIlkay Erdoğan0Sema OzerTevfik KaragözAlpay CelikerSüheyla OzkutluDursun AlehanPediatric Cardiology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. We performed a study to examine the clinical use of carvedilol, its dosage and its effects on systolic functions in children. Twenty-one patients with dilated cardiomyopathy who were treated with carvedilol adjacent to standard heart failure therapy were enrolled in the study. Echocardiographic assessment was obtained before and during carvedilol therapy, and left ventricular fractional shortening and left ventricular ejection fraction were determined in order to estimate left ventricular function. At a follow-up of six months, left ventricular ejection fraction and fractional shortening significantly improved from 38 +/- 10% to 53 +/- 13% and from 19 +/- 6 % to 27 +/- 8%, respectively, following carvedilol treatment. The results of the present study indicate that carvedilol is well tolerated in children with dilated cardiomyopathy and there is a significant improvement in the clinical status and left ventricular ejection fraction in patients not responding to conventional therapy. Patient selection criteria, optimal timing of carvedilol therapy, its dosage and its long-term effects need to be investigated with multi-institutional trials and large numbers of patients. https://turkjpediatr.org/article/view/2315 |
| spellingShingle | Ilkay Erdoğan Sema Ozer Tevfik Karagöz Alpay Celiker Süheyla Ozkutlu Dursun Alehan Treatment of dilated cardiomyopathy with carvedilol in children The Turkish Journal of Pediatrics |
| title | Treatment of dilated cardiomyopathy with carvedilol in children |
| title_full | Treatment of dilated cardiomyopathy with carvedilol in children |
| title_fullStr | Treatment of dilated cardiomyopathy with carvedilol in children |
| title_full_unstemmed | Treatment of dilated cardiomyopathy with carvedilol in children |
| title_short | Treatment of dilated cardiomyopathy with carvedilol in children |
| title_sort | treatment of dilated cardiomyopathy with carvedilol in children |
| url | https://turkjpediatr.org/article/view/2315 |
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