DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation

DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation

Abstract Metastasis is a leading cause of treatment failure and high mortality in non-small cell lung cancer (NSCLC). Recently, we demonstrated that DEAD box helicase 39B (DDX39B) was upregulated and activated metabolic reprogramming in colorectal cancer and hepatocellular carcinoma. However, the fu...

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Main Authors: Hang Yuan, Qin Li, Liang Li, Gang Zhao, Jie Zhang, Tianyu Feng, Yafei Guo, Qiming Kou, Siqi Li, Shan Li, Minghui Zhao, Guanru Wang, Qijing Wang, Jie Qu, Huayang Yu, Hongbai Chen, Lunxu Liu, Kai Li, Ping Lin
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02305-9
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