Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration

Abstract The nucleus pulposus (NP) plays a vital role in intervertebral disc degeneration (IVDD). Previous studies have revealed cellular heterogeneity in NP tissue during IVDD progression. However, the cellular and molecular alterations of diverse cell clusters during IVDD remain to be fully elucid...

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Bibliographic Details
Main Authors: Shu Jia, Hongmei Liu, Tao Yang, Sheng Gao, Dongru Li, Zhenyu Zhang, Zifang Zhang, Xu Gao, Yanhu Liang, Xiao Liang, Yexin Wang, Chunyang Meng
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Intervertebral disc degeneration
Nucleus pulposus
Single-cell RNA sequencing
Online Access:https://doi.org/10.1038/s41598-024-78675-x
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