Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases

Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases

Novel coumarin derivatives were synthesised and tested for their cytotoxicity against human cancer cells (PC-3 and MDA-MB-231). Compounds 5, 4b, and 4a possessed potent cytotoxic activity against PC-3 cells with IC50 3.56, 8.99, and 10.22 µM, respectively. Compound 4c displayed cytotoxicity more tha...

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Bibliographic Details
Main Authors: Lina M. A. Abdel Ghany, Tarek S. Ibrahim, Abdulrahman S. Alharbi, Mohamed S. Abdel-Aziz, Eman M. El-labbad, Mohamed Elagawany, Noha Ryad
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Coumarins
PC-3
cytotoxicity
apoptosis
docking
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2311157
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https://www.tandfonline.com/doi/10.1080/14756366.2024.2311157

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