Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris
As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remissi...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2008/875394 |
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| author | Joanna Narbutt Jolanta Lukamowicz Jarosław Bogaczewicz Anna Sysa-Jedrzejowska Jolanta Dorota Torzecka Aleksandra Lesiak |
| author_facet | Joanna Narbutt Jolanta Lukamowicz Jarosław Bogaczewicz Anna Sysa-Jedrzejowska Jolanta Dorota Torzecka Aleksandra Lesiak |
| author_sort | Joanna Narbutt |
| collection | DOAJ |
| description | As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission. 19 sera taken from healthy subjects served as the controls. Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls (P<.05). In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (rP=0.46;P<.05). We also found a negative correlation between TNF-α level and pemphigus antibodies titer in the patients from the remission group (rS=−0.47303;P<.02). Our data suggest that IL-6 and TNF-α may be involved in maintaining immunological disturbances in remission stage of PV. |
| format | Article |
| id | doaj-art-88630fcd6616450c81dd88b009a9ce8b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-88630fcd6616450c81dd88b009a9ce8b2025-02-03T01:23:59ZengWileyMediators of Inflammation0962-93511466-18612008-01-01200810.1155/2008/875394875394Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus VulgarisJoanna Narbutt0Jolanta Lukamowicz1Jarosław Bogaczewicz2Anna Sysa-Jedrzejowska3Jolanta Dorota Torzecka4Aleksandra Lesiak5Department of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandLaboratory of Immunochemical Research, Polish Mother's Memorial Hospital Research Institute, 93-338 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Immunodermatology, Medical University of Lodz, 94-017 Lodz, PolandDepartment of Dermatology, Medical University of Lodz, 94-017 Lodz, PolandAs most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission. 19 sera taken from healthy subjects served as the controls. Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls (P<.05). In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (rP=0.46;P<.05). We also found a negative correlation between TNF-α level and pemphigus antibodies titer in the patients from the remission group (rS=−0.47303;P<.02). Our data suggest that IL-6 and TNF-α may be involved in maintaining immunological disturbances in remission stage of PV.http://dx.doi.org/10.1155/2008/875394 |
| spellingShingle | Joanna Narbutt Jolanta Lukamowicz Jarosław Bogaczewicz Anna Sysa-Jedrzejowska Jolanta Dorota Torzecka Aleksandra Lesiak Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris Mediators of Inflammation |
| title | Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris |
| title_full | Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris |
| title_fullStr | Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris |
| title_full_unstemmed | Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris |
| title_short | Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris |
| title_sort | serum concentration of interleukin 6 is increased both in active and remission stages of pemphigus vulgaris |
| url | http://dx.doi.org/10.1155/2008/875394 |
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