Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants
Abstract. The production of bioactive compounds from traditional Chinese medicine and medicinal plants mainly depends on the extraction and separation from medicinal materials, which is time-consuming, laborious, and requires large amounts of medicinal resources. As the market demand for bioactive c...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2024-06-01
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| Series: | Science of Traditional Chinese Medicine |
| Online Access: | http://journals.lww.com/10.1097/st9.0000000000000027 |
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| author | Shuang Liu Shuo Yang Ping Su |
| author_facet | Shuang Liu Shuo Yang Ping Su |
| author_sort | Shuang Liu |
| collection | DOAJ |
| description | Abstract. The production of bioactive compounds from traditional Chinese medicine and medicinal plants mainly depends on the extraction and separation from medicinal materials, which is time-consuming, laborious, and requires large amounts of medicinal resources. As the market demand for bioactive compounds increases, the shortage of medicinal resources tops the list. For a stable and sustainable supply of affordable bioactive compounds, it is necessary to optimize chemosynthetic and biosynthetic pathways. Although some progress has been made in chemocatalysis and biosynthesis, there are drawbacks and bottlenecks in current approaches. We hold the opinion that the combination of chemosynthesis and biosynthesis will be the key direction to efficiently produce bioactive compounds. Chemo-enzymatic synthesis, a strategy that combines biosynthesis and chemosynthesis, is an alternative approach for the heterologous production of bioactive compounds. This paper reviews the recent advances in the chemo-enzymatic synthesis of bioactive compounds derived from traditional Chinese medicine and medicinal plants, highlights the potential application, and presents our perspectives for future research. |
| format | Article |
| id | doaj-art-8862e080ae6d4dfa8c179347b10062ba |
| institution | DOAJ |
| issn | 2836-922X 2836-9211 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Science of Traditional Chinese Medicine |
| spelling | doaj-art-8862e080ae6d4dfa8c179347b10062ba2025-08-20T03:17:55ZengWolters Kluwer Health/LWWScience of Traditional Chinese Medicine2836-922X2836-92112024-06-01229510310.1097/st9.0000000000000027202406000-00003Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plantsShuang Liu0Shuo Yang1Ping Su2a Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, Chinaa Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, Chinab State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaAbstract. The production of bioactive compounds from traditional Chinese medicine and medicinal plants mainly depends on the extraction and separation from medicinal materials, which is time-consuming, laborious, and requires large amounts of medicinal resources. As the market demand for bioactive compounds increases, the shortage of medicinal resources tops the list. For a stable and sustainable supply of affordable bioactive compounds, it is necessary to optimize chemosynthetic and biosynthetic pathways. Although some progress has been made in chemocatalysis and biosynthesis, there are drawbacks and bottlenecks in current approaches. We hold the opinion that the combination of chemosynthesis and biosynthesis will be the key direction to efficiently produce bioactive compounds. Chemo-enzymatic synthesis, a strategy that combines biosynthesis and chemosynthesis, is an alternative approach for the heterologous production of bioactive compounds. This paper reviews the recent advances in the chemo-enzymatic synthesis of bioactive compounds derived from traditional Chinese medicine and medicinal plants, highlights the potential application, and presents our perspectives for future research.http://journals.lww.com/10.1097/st9.0000000000000027 |
| spellingShingle | Shuang Liu Shuo Yang Ping Su Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants Science of Traditional Chinese Medicine |
| title | Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants |
| title_full | Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants |
| title_fullStr | Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants |
| title_full_unstemmed | Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants |
| title_short | Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants |
| title_sort | chemo enzymatic synthesis of bioactive compounds from traditional chinese medicine and medicinal plants |
| url | http://journals.lww.com/10.1097/st9.0000000000000027 |
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