Leptin and inflammatory pathways in the Alzheimer's disease continuum: Implications for glial activation and neuropsychiatric symptoms

Leptin and inflammatory pathways in the Alzheimer's disease continuum: Implications for glial activation and neuropsychiatric symptoms

Introduction: Chronic peripheral inflammation triggered by adipokine release may extend to the brain, potentially influencing the pathological progression of Alzheimer's disease (AD) and neuropsychiatric symptoms (NPS). However, it remains unclear whether and how leptin contributes to the link...

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Main Authors: Fumihiko Yasuno, Kazuyuki Nakagome, Yoshie Omachi, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, Kensaku Kasuga, Takeshi Ikeuchi, Akinori Takeda, Takashi Sakurai, Kengo Ito, Takashi Kato
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Alzheimer's disease
Leptin
Adiposity
Neuropsychiatric symptoms
Positron emission tomography
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354625000766
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