Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction
Diabetes mellitus erectile dysfunction (DMED) is a severe complication highly prevalent among male diabetic patients, with a global prevalence exceeding 50%, while current therapies exhibit limited efficacy. Adipose-derived stem cells (ADSCs) have emerged as a research focus for DMED treatment due t...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1634521/full |
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| author | Jingbang Liu Tao Jiang |
| author_facet | Jingbang Liu Tao Jiang |
| author_sort | Jingbang Liu |
| collection | DOAJ |
| description | Diabetes mellitus erectile dysfunction (DMED) is a severe complication highly prevalent among male diabetic patients, with a global prevalence exceeding 50%, while current therapies exhibit limited efficacy. Adipose-derived stem cells (ADSCs) have emerged as a research focus for DMED treatment due to their accessibility, multipotent differentiation potential and paracrine properties. This article systematically reviews the mechanisms of ADSCs in treating DMED: ADSCs improve cavernous vascularization and endothelial function, inhibit fibrosis and increase smooth muscle content, ameliorate cavernous neuropathy, alleviate programmed cell death in cavernous tissues and reverse phenotypic transformation of cavernous smooth muscle. Additionally, clinical studies on ADSCs therapy for DMED are summarized, along with methods to enhance the efficacy of ADSCs treatment for ED. However, further researches on the underlying mechanisms and clinical trials are needed to advance ADSC from basic research to precision medicine. |
| format | Article |
| id | doaj-art-885e2b70eb4840a6acda4fa47c728376 |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-885e2b70eb4840a6acda4fa47c7283762025-08-20T03:12:46ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16345211634521Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunctionJingbang LiuTao JiangDiabetes mellitus erectile dysfunction (DMED) is a severe complication highly prevalent among male diabetic patients, with a global prevalence exceeding 50%, while current therapies exhibit limited efficacy. Adipose-derived stem cells (ADSCs) have emerged as a research focus for DMED treatment due to their accessibility, multipotent differentiation potential and paracrine properties. This article systematically reviews the mechanisms of ADSCs in treating DMED: ADSCs improve cavernous vascularization and endothelial function, inhibit fibrosis and increase smooth muscle content, ameliorate cavernous neuropathy, alleviate programmed cell death in cavernous tissues and reverse phenotypic transformation of cavernous smooth muscle. Additionally, clinical studies on ADSCs therapy for DMED are summarized, along with methods to enhance the efficacy of ADSCs treatment for ED. However, further researches on the underlying mechanisms and clinical trials are needed to advance ADSC from basic research to precision medicine.https://www.frontiersin.org/articles/10.3389/fmed.2025.1634521/fulladipose-derived stem cellsdiabetic mellitus erectile dysfunctionvascular regenerationnerve repairphenotypic transformation |
| spellingShingle | Jingbang Liu Tao Jiang Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction Frontiers in Medicine adipose-derived stem cells diabetic mellitus erectile dysfunction vascular regeneration nerve repair phenotypic transformation |
| title | Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction |
| title_full | Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction |
| title_fullStr | Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction |
| title_full_unstemmed | Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction |
| title_short | Current status and advances in adipose-derived stem cells therapy for diabetes mellitus erectile dysfunction |
| title_sort | current status and advances in adipose derived stem cells therapy for diabetes mellitus erectile dysfunction |
| topic | adipose-derived stem cells diabetic mellitus erectile dysfunction vascular regeneration nerve repair phenotypic transformation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1634521/full |
| work_keys_str_mv | AT jingbangliu currentstatusandadvancesinadiposederivedstemcellstherapyfordiabetesmellituserectiledysfunction AT taojiang currentstatusandadvancesinadiposederivedstemcellstherapyfordiabetesmellituserectiledysfunction |