Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer
Objective Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for soli...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2093994 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850098242825486336 |
|---|---|
| author | Jing Zhao Huidan Lu Danxia Xu Ruiqi Sun Chengyu Fang Qiyu Zhao Chang He Yuwei Pan Feng Xu Tianan Jiang |
| author_facet | Jing Zhao Huidan Lu Danxia Xu Ruiqi Sun Chengyu Fang Qiyu Zhao Chang He Yuwei Pan Feng Xu Tianan Jiang |
| author_sort | Jing Zhao |
| collection | DOAJ |
| description | Objective Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer.Methods We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their use as a complementary agent for nsPEF treatment.Results Our results showed that neutrophil-mediated delivery of liposomal-gemcitabine (NE/Lip-GEM) efficiently inhibited the growth of pancreatic tumors in mice whose has been treated with incomplete nsPEF ablation.Conclusions The combination of nsPEF and NE/Lip-GEM may be a promising synergistic strategy for pancreatic cancer therapy. |
| format | Article |
| id | doaj-art-885b47cf43134cb4ad590d3106daaf4e |
| institution | DOAJ |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-885b47cf43134cb4ad590d3106daaf4e2025-08-20T02:40:47ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572022-12-013911026103510.1080/02656736.2022.2093994Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancerJing Zhao0Huidan Lu1Danxia Xu2Ruiqi Sun3Chengyu Fang4Qiyu Zhao5Chang He6Yuwei Pan7Feng Xu8Tianan Jiang9Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaObjective Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer.Methods We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their use as a complementary agent for nsPEF treatment.Results Our results showed that neutrophil-mediated delivery of liposomal-gemcitabine (NE/Lip-GEM) efficiently inhibited the growth of pancreatic tumors in mice whose has been treated with incomplete nsPEF ablation.Conclusions The combination of nsPEF and NE/Lip-GEM may be a promising synergistic strategy for pancreatic cancer therapy.https://www.tandfonline.com/doi/10.1080/02656736.2022.2093994Pancreatic cancernanosecond pulsed electric fieldcombination cancer therapyneutrophils |
| spellingShingle | Jing Zhao Huidan Lu Danxia Xu Ruiqi Sun Chengyu Fang Qiyu Zhao Chang He Yuwei Pan Feng Xu Tianan Jiang Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer International Journal of Hyperthermia Pancreatic cancer nanosecond pulsed electric field combination cancer therapy neutrophils |
| title | Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer |
| title_full | Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer |
| title_fullStr | Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer |
| title_full_unstemmed | Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer |
| title_short | Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer |
| title_sort | neutrophil membrane coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer |
| topic | Pancreatic cancer nanosecond pulsed electric field combination cancer therapy neutrophils |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2093994 |
| work_keys_str_mv | AT jingzhao neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT huidanlu neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT danxiaxu neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT ruiqisun neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT chengyufang neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT qiyuzhao neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT changhe neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT yuweipan neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT fengxu neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer AT tiananjiang neutrophilmembranecoatednanoparticlesforenhancednanosecondpulsedelectricfieldtreatmentofpancreaticcancer |