Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease
Chronic hepatitis B has highly a dynamic course with significant fluctuations of HBV-DNA and ALT impeding assessment of disease activity. New biomarkers of inflammatory versus noninflammatory stages of HBV infection are urgently needed. Cytokeratin 18 epitope M30 (M30 CK-18) is a sensitive marker of...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3480234 |
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| author | Magdalena Świderska Jerzy Jaroszewicz Anna Parfieniuk-Kowerda Magdalena Rogalska-Płońska Agnieszka Stawicka Anatol Panasiuk Robert Flisiak |
| author_facet | Magdalena Świderska Jerzy Jaroszewicz Anna Parfieniuk-Kowerda Magdalena Rogalska-Płońska Agnieszka Stawicka Anatol Panasiuk Robert Flisiak |
| author_sort | Magdalena Świderska |
| collection | DOAJ |
| description | Chronic hepatitis B has highly a dynamic course with significant fluctuations of HBV-DNA and ALT impeding assessment of disease activity. New biomarkers of inflammatory versus noninflammatory stages of HBV infection are urgently needed. Cytokeratin 18 epitope M30 (M30 CK-18) is a sensitive marker of cell death. We aimed to investigate an association between serum M30 CK-18 and histological activity and phase of HBV infection. 150 Caucasian patients with HBV-infection were included in the study. Serum M30 CK-18 levels reflected phase of disease, being significantly higher in both HBeAg(+) and HBeAg(−) hepatitis B in comparison to HBsAg(+) carrier groups. The highest serum M30 CK-18 levels were observed in subjects with the most advanced stages of HBV. Moreover, its serum concentrations correlated with both inflammatory activity and fibrosis advancement (ANOVA P<0.001). Importantly, serum M30 CK-18 levels were able to discriminate patients with mild versus moderate-advanced fibrosis (AUC: 0.86) and mild versus active liver inflammation (AUC: 0.79). M30 CK-18 serum concentration has good sensitivity and specificity in discriminating mild versus moderate/severe fibrosis and inflammation even in patients with normal ALT activity. This study suggests M30 CK-18 as a potential noninvasive marker of disease activity and also a marker of phase of persistent HBV infection. |
| format | Article |
| id | doaj-art-885293c900ef41bcb1d18331e694c378 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-885293c900ef41bcb1d18331e694c3782025-08-20T03:38:06ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/34802343480234Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of DiseaseMagdalena Świderska0Jerzy Jaroszewicz1Anna Parfieniuk-Kowerda2Magdalena Rogalska-Płońska3Agnieszka Stawicka4Anatol Panasiuk5Robert Flisiak6Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, PolandChronic hepatitis B has highly a dynamic course with significant fluctuations of HBV-DNA and ALT impeding assessment of disease activity. New biomarkers of inflammatory versus noninflammatory stages of HBV infection are urgently needed. Cytokeratin 18 epitope M30 (M30 CK-18) is a sensitive marker of cell death. We aimed to investigate an association between serum M30 CK-18 and histological activity and phase of HBV infection. 150 Caucasian patients with HBV-infection were included in the study. Serum M30 CK-18 levels reflected phase of disease, being significantly higher in both HBeAg(+) and HBeAg(−) hepatitis B in comparison to HBsAg(+) carrier groups. The highest serum M30 CK-18 levels were observed in subjects with the most advanced stages of HBV. Moreover, its serum concentrations correlated with both inflammatory activity and fibrosis advancement (ANOVA P<0.001). Importantly, serum M30 CK-18 levels were able to discriminate patients with mild versus moderate-advanced fibrosis (AUC: 0.86) and mild versus active liver inflammation (AUC: 0.79). M30 CK-18 serum concentration has good sensitivity and specificity in discriminating mild versus moderate/severe fibrosis and inflammation even in patients with normal ALT activity. This study suggests M30 CK-18 as a potential noninvasive marker of disease activity and also a marker of phase of persistent HBV infection.http://dx.doi.org/10.1155/2017/3480234 |
| spellingShingle | Magdalena Świderska Jerzy Jaroszewicz Anna Parfieniuk-Kowerda Magdalena Rogalska-Płońska Agnieszka Stawicka Anatol Panasiuk Robert Flisiak Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease Mediators of Inflammation |
| title | Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease |
| title_full | Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease |
| title_fullStr | Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease |
| title_full_unstemmed | Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease |
| title_short | Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease |
| title_sort | serum cytokeratin 18 m30 levels in chronic hepatitis b reflect both phase and histological activities of disease |
| url | http://dx.doi.org/10.1155/2017/3480234 |
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