Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study
The role of adenovirus infection in the SARS is significant but every year this group of infections makes up to 30 % of general infectious morbidity. Nowadays features of nonspecific immune defence in patients with adenovirus infection are insufficiently studied. Particularly acute AVI problem appea...
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| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2018-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/132123/130835 |
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| author | V. D. Moskaliuk I. V. Balaniuk A. S. Sydorchuk Kh. I. Vozna M. O. Andruschak I. V. Rudan |
| author_facet | V. D. Moskaliuk I. V. Balaniuk A. S. Sydorchuk Kh. I. Vozna M. O. Andruschak I. V. Rudan |
| author_sort | V. D. Moskaliuk |
| collection | DOAJ |
| description | The role of adenovirus infection in the SARS is significant but every year this group of infections makes up to 30 % of general infectious morbidity. Nowadays features of nonspecific immune defence in patients with adenovirus infection are insufficiently studied. Particularly acute AVI problem appears to clinicians and scientists as a contagious disease, which is rapidly spreading in organized collectives, among military personnel, students.
Purpose. To study the reactive response of polymorphonuclear granulocytes in the peripheral blood of adult patients with adenovirus infection.
Materials and methods. 37 volunteers with SARS signs (Unified Protocol Criteria) were involved in this “case – control” type study. Absolute and relative quantities of the main immune cells populations in the peripheral blood were analyzed. Immunohematological indicators which characterize reactive response of the main non-specific immune cells were calculated. Clinical diagnosis was confirmed by the serological method of complement fixation test in paired sera and using adenoviruses common soluble complement-fixing antigen.
Results. Neutrophil granulocytes reactivity increased by 83.92 % indicating these cells activation by cytokine system. The inflammatory process is accompanied by an increase in leukocytes absolute count – 19.76 %, band neutrophil leukocytes - in 2.18 times; lymphocytes – 30.30 % and monocytes – 48.15 %.
Conclusions. Aforementioned means that there are different types of immune response to adenovirus infection antigens. Patients immune reactivity decreasing by 14.86 % means that specific immune response is formed later. Method of neutrophils reactive response evaluation can be used by practicing doctors for the early prediction of possible anti-infectious protection system alteration. |
| format | Article |
| id | doaj-art-884eeea83c754387ac1eb79a162ebe55 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-884eeea83c754387ac1eb79a162ebe552025-08-20T01:58:16ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102018-06-01333934310.14739/2310-1210.2018.3.132123Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes studyV. D. MoskaliukI. V. BalaniukA. S. SydorchukKh. I. VoznaM. O. AndruschakI. V. RudanThe role of adenovirus infection in the SARS is significant but every year this group of infections makes up to 30 % of general infectious morbidity. Nowadays features of nonspecific immune defence in patients with adenovirus infection are insufficiently studied. Particularly acute AVI problem appears to clinicians and scientists as a contagious disease, which is rapidly spreading in organized collectives, among military personnel, students. Purpose. To study the reactive response of polymorphonuclear granulocytes in the peripheral blood of adult patients with adenovirus infection. Materials and methods. 37 volunteers with SARS signs (Unified Protocol Criteria) were involved in this “case – control” type study. Absolute and relative quantities of the main immune cells populations in the peripheral blood were analyzed. Immunohematological indicators which characterize reactive response of the main non-specific immune cells were calculated. Clinical diagnosis was confirmed by the serological method of complement fixation test in paired sera and using adenoviruses common soluble complement-fixing antigen. Results. Neutrophil granulocytes reactivity increased by 83.92 % indicating these cells activation by cytokine system. The inflammatory process is accompanied by an increase in leukocytes absolute count – 19.76 %, band neutrophil leukocytes - in 2.18 times; lymphocytes – 30.30 % and monocytes – 48.15 %. Conclusions. Aforementioned means that there are different types of immune response to adenovirus infection antigens. Patients immune reactivity decreasing by 14.86 % means that specific immune response is formed later. Method of neutrophils reactive response evaluation can be used by practicing doctors for the early prediction of possible anti-infectious protection system alteration.http://zmj.zsmu.edu.ua/article/view/132123/130835adenovirus infectionscellular reactivityneutrophilsactive immune response |
| spellingShingle | V. D. Moskaliuk I. V. Balaniuk A. S. Sydorchuk Kh. I. Vozna M. O. Andruschak I. V. Rudan Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study Zaporožskij Medicinskij Žurnal adenovirus infections cellular reactivity neutrophils active immune response |
| title | Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study |
| title_full | Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study |
| title_fullStr | Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study |
| title_full_unstemmed | Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study |
| title_short | Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study |
| title_sort | adenovirus infection in adults reactive response of polymorphonuclear neutrophilic leukocytes study |
| topic | adenovirus infections cellular reactivity neutrophils active immune response |
| url | http://zmj.zsmu.edu.ua/article/view/132123/130835 |
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