CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS
In the present review we collected the main studies regarding the role of chitinase-like proteins (CLPs), belonging to the family of Glyco_18 domain-containing proteins, in different cancers. In humans, 3 chitinaselike proteins have been identified: YKL-40 (CHI3L1), YKL-39 (CHI3L2) and stabilin-1-...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2018-09-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/822 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849408331610849280 |
|---|---|
| author | I. V. Larionova T. N. Sevastyanova A. A. Rakina N. V. Cherdyntseva Ju. G. Kzhyshkowska |
| author_facet | I. V. Larionova T. N. Sevastyanova A. A. Rakina N. V. Cherdyntseva Ju. G. Kzhyshkowska |
| author_sort | I. V. Larionova |
| collection | DOAJ |
| description | In the present review we collected the main studies regarding the role of chitinase-like proteins (CLPs), belonging to the family of Glyco_18 domain-containing proteins, in different cancers. In humans, 3 chitinaselike proteins have been identified: YKL-40 (CHI3L1), YKL-39 (CHI3L2) and stabilin-1-interacting chitinase-like protein (SI-CLP). CLPs are produced by several types of cells and combine the properties of cytokines and growth factors. The high levels of CLPs were identified in the circulation of the patients with inflammatory diseases and various types of tumors. We highlighted the main known functions of CLPs in normal and pathological conditions, their contribution to metastasis development, angiogenesis, invasion and other processes in cancer, the correlation of the levels of CLPs with tumour progression. Our data also contribute to the understanding of question how CLP could be useful for cancer patient benefit. |
| format | Article |
| id | doaj-art-884e2d1f64aa48579cc3e6171751ab31 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-884e2d1f64aa48579cc3e6171751ab312025-08-20T03:35:48ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-09-011749910510.21294/1814-4861-2018-17-4-99-105568CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTSI. V. Larionova0T. N. Sevastyanova1A. A. Rakina2N. V. Cherdyntseva3Ju. G. Kzhyshkowska4Tomsk State University Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesTomsk State University Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of HeidelbergNational Research Tomsk Polytechnic UniversityTomsk State University Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesTomsk State University Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg German Red Cross Blood Service Baden-Württemberg-HessenIn the present review we collected the main studies regarding the role of chitinase-like proteins (CLPs), belonging to the family of Glyco_18 domain-containing proteins, in different cancers. In humans, 3 chitinaselike proteins have been identified: YKL-40 (CHI3L1), YKL-39 (CHI3L2) and stabilin-1-interacting chitinase-like protein (SI-CLP). CLPs are produced by several types of cells and combine the properties of cytokines and growth factors. The high levels of CLPs were identified in the circulation of the patients with inflammatory diseases and various types of tumors. We highlighted the main known functions of CLPs in normal and pathological conditions, their contribution to metastasis development, angiogenesis, invasion and other processes in cancer, the correlation of the levels of CLPs with tumour progression. Our data also contribute to the understanding of question how CLP could be useful for cancer patient benefit.https://www.siboncoj.ru/jour/article/view/822chitinase-like proteinsclpykl-30ykl-40si-clpcancertumor progression |
| spellingShingle | I. V. Larionova T. N. Sevastyanova A. A. Rakina N. V. Cherdyntseva Ju. G. Kzhyshkowska CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS Сибирский онкологический журнал chitinase-like proteins clp ykl-30 ykl-40 si-clp cancer tumor progression |
| title | CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS |
| title_full | CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS |
| title_fullStr | CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS |
| title_full_unstemmed | CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS |
| title_short | CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS |
| title_sort | chitinase like proteins as promising markers in cancer patients |
| topic | chitinase-like proteins clp ykl-30 ykl-40 si-clp cancer tumor progression |
| url | https://www.siboncoj.ru/jour/article/view/822 |
| work_keys_str_mv | AT ivlarionova chitinaselikeproteinsaspromisingmarkersincancerpatients AT tnsevastyanova chitinaselikeproteinsaspromisingmarkersincancerpatients AT aarakina chitinaselikeproteinsaspromisingmarkersincancerpatients AT nvcherdyntseva chitinaselikeproteinsaspromisingmarkersincancerpatients AT jugkzhyshkowska chitinaselikeproteinsaspromisingmarkersincancerpatients |