Antibiotic tolerance due to restriction of cAMP-Crp regulation by mannitol, a non-glucose-family PTS carbon source

Antibiotic tolerance due to restriction of cAMP-Crp regulation by mannitol, a non-glucose-family PTS carbon source

ABSTRACT Enzyme-IIA (EIIAGlc, Crr) of the phosphotransferase system (PTS) connects the uptake of glucose-family sugars to the cAMP-Crp regulatory cascade; phosphorylated EIIAGlc enhances cAMP-Crp activity, which then contributes to the antibiotic-mediated accumulation of reactive oxygen species (ROS...

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Main Authors: Weiwei Zhu, Miaomiao Chen, Xue Zhang, Jie Su, Xinyang Zhang, Yuejuan Nong, Bowen Wang, Weihong Guo, Yunxin Xue, Dai Wang, Yiqun Liao, Jianjun Niu, Yuzhi Hong, Karl Drlica, Xilin Zhao
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mSphere
Subjects:
antibiotic tolerance
mannitol
mannose
sorbitol
cAMP-Crp
Escherichia coli
Online Access:https://journals.asm.org/doi/10.1128/msphere.00772-24
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