Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans
As an irreplaceable dietary constituent, lipids play a vital important role in health, but their effects on aging process and longevity are still not well known yet. In this paper, the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects o...
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002518 |
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| author | Yanan Wang Jiachen Shi Kun Liu Yu Wang Yongjiang Xu Yuanfa Liu |
| author_facet | Yanan Wang Jiachen Shi Kun Liu Yu Wang Yongjiang Xu Yuanfa Liu |
| author_sort | Yanan Wang |
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| description | As an irreplaceable dietary constituent, lipids play a vital important role in health, but their effects on aging process and longevity are still not well known yet. In this paper, the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects of different edible oils on senescence and lifespan. The results showed that teaseed oil (TO) could prolong the life expectancy and slow down the aging process of C. elegans. Compared to the control group, the intake of lard oil (LO) and TO increased the expression levels of genes related to inhibition of protein aggregation (akt-1, daf-16, hsf-1, hsp-16.2) and lipid metabolism (daf-7, daf-1, mdt-15, lipl-4, fat-5, fat-6, fat-7), with a more significant alteration in TO group. Metabolomics revealed that palm oil can upregulated plenty of fatty acids (palmitic acid, stearic acid, tetracosanoic acid), together with some amino acids (tryptophan, L-aspartate, L-valine) and carbohydrate (D-glucose), while the trend was opposite in TO group. Besides, moderate-to-strong correlations were found between differential metabolites and changed genes. In general, this paper claimed that TO could prolong lifespan and slow down aging process via regulating the lipids, amino acids and carbohydrates metabolism. |
| format | Article |
| id | doaj-art-88457051482e43f88b2fe4ebd21999f5 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-88457051482e43f88b2fe4ebd21999f52025-02-03T11:09:30ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-0112413911401Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegansYanan Wang0Jiachen Shi1Kun Liu2Yu Wang3Yongjiang Xu4Yuanfa Liu5State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaCorresponding author at: School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaAs an irreplaceable dietary constituent, lipids play a vital important role in health, but their effects on aging process and longevity are still not well known yet. In this paper, the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects of different edible oils on senescence and lifespan. The results showed that teaseed oil (TO) could prolong the life expectancy and slow down the aging process of C. elegans. Compared to the control group, the intake of lard oil (LO) and TO increased the expression levels of genes related to inhibition of protein aggregation (akt-1, daf-16, hsf-1, hsp-16.2) and lipid metabolism (daf-7, daf-1, mdt-15, lipl-4, fat-5, fat-6, fat-7), with a more significant alteration in TO group. Metabolomics revealed that palm oil can upregulated plenty of fatty acids (palmitic acid, stearic acid, tetracosanoic acid), together with some amino acids (tryptophan, L-aspartate, L-valine) and carbohydrate (D-glucose), while the trend was opposite in TO group. Besides, moderate-to-strong correlations were found between differential metabolites and changed genes. In general, this paper claimed that TO could prolong lifespan and slow down aging process via regulating the lipids, amino acids and carbohydrates metabolism.http://www.sciencedirect.com/science/article/pii/S2213453022002518Caenorhabditis elegansLipidsLifespanFood omicsGene expression |
| spellingShingle | Yanan Wang Jiachen Shi Kun Liu Yu Wang Yongjiang Xu Yuanfa Liu Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans Food Science and Human Wellness Caenorhabditis elegans Lipids Lifespan Food omics Gene expression |
| title | Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans |
| title_full | Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans |
| title_fullStr | Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans |
| title_full_unstemmed | Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans |
| title_short | Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans |
| title_sort | metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in caenorhabditis elegans |
| topic | Caenorhabditis elegans Lipids Lifespan Food omics Gene expression |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002518 |
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