Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia–reperfusion

Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia–reperfusion

Abstract We examined if the hindlimb muscle ischemia–reperfusion (IR) alters ASIC3‐mediated muscle afferent activity in regulating the exercise pressor reflex (EPR). APETx2 (an ASIC3 antagonist) was arterially injected into the hindlimb before static muscle contraction. The mean arterial pressure (M...

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Bibliographic Details
Main Authors: Lu Qin, Xuexin Zhang, Jianhua Li
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Physiological Reports
Subjects:
blood pressure
exercise
peripheral artery disease
Online Access:https://doi.org/10.14814/phy2.70457
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