Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels
Abstract Objective This study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease. Methods We collected clinical data from 10 patients with AGCT-NEL,...
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BMC
2024-12-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-024-01529-5 |
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| author | Wei Weng Yaomeng Chen Ze Liu Weiqian Chen Jiejie Hu Huihui Chen Xindian Pan Hai Wu Xinle Chi |
| author_facet | Wei Weng Yaomeng Chen Ze Liu Weiqian Chen Jiejie Hu Huihui Chen Xindian Pan Hai Wu Xinle Chi |
| author_sort | Wei Weng |
| collection | DOAJ |
| description | Abstract Objective This study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease. Methods We collected clinical data from 10 patients with AGCT-NEL, confirmed by pathology, treated at our hospital from January 2016 to January 2024. We retrospectively analyzed the MRI features of primary and metastatic lesions from aspects such as shape, edge characteristics, MRI signal, and enhancement features. Results A total of 10 AGCT-NEL patients were included in this study, aged 28 to 81 years, with an average age of 54 ± 16 years. The primary tumors primarily presented as unilocular cystic, solid, and cystic-solid types. The solid components showed isointense to slightly hypointense signals on T1-weighted imaging (T1WI), slightly hyperintense signals on T2-weighted imaging (T2WI), and high signals on diffusion-weighted imaging (DWI), with possible internal hemorrhage or cystic degeneration. The cystic components exhibited low signal on T1WI, high signal on T2WI, uniform wall thickness, and no wall nodules, typically showing hemorrhagic fluid levels. Honeycomb and Swiss cheese signs are sometimes observed in cystic-solid tumors. All metastatic lesions were cystic (either unilocular or multilocular), presenting low signal on T1WI and high signal on T2WI, with no wall nodules and possible internal hemorrhagic fluid levels. The multilocular metastatic tumors demonstrated unevenly thickened partitions, also displaying honeycomb and Swiss cheese signs. Conclusion The MRI characteristics of primary and metastatic lesions in AGCT-NEL possess specific features, such as signs of hemorrhage, absence of wall nodules in the cystic portions of the tumors, and distinctive honeycomb and Swiss cheese signs, with metastatic lesions being cystic. Understanding these features can aid in improving preoperative diagnostic capabilities and reducing misdiagnosis. |
| format | Article |
| id | doaj-art-884339acdb8041ce891ed19016b65f08 |
| institution | Kabale University |
| issn | 1471-2342 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj-art-884339acdb8041ce891ed19016b65f082025-01-05T12:50:10ZengBMCBMC Medical Imaging1471-23422024-12-0124111010.1186/s12880-024-01529-5Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levelsWei Weng0Yaomeng Chen1Ze Liu2Weiqian Chen3Jiejie Hu4Huihui Chen5Xindian Pan6Hai Wu7Xinle Chi8Department of Radiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Radiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Radiology, Ningbo Ninth HospitalDepartment of Respiratory Medicine, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Pathology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Pathology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Pathology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Radiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Radiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s HospitalAbstract Objective This study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease. Methods We collected clinical data from 10 patients with AGCT-NEL, confirmed by pathology, treated at our hospital from January 2016 to January 2024. We retrospectively analyzed the MRI features of primary and metastatic lesions from aspects such as shape, edge characteristics, MRI signal, and enhancement features. Results A total of 10 AGCT-NEL patients were included in this study, aged 28 to 81 years, with an average age of 54 ± 16 years. The primary tumors primarily presented as unilocular cystic, solid, and cystic-solid types. The solid components showed isointense to slightly hypointense signals on T1-weighted imaging (T1WI), slightly hyperintense signals on T2-weighted imaging (T2WI), and high signals on diffusion-weighted imaging (DWI), with possible internal hemorrhage or cystic degeneration. The cystic components exhibited low signal on T1WI, high signal on T2WI, uniform wall thickness, and no wall nodules, typically showing hemorrhagic fluid levels. Honeycomb and Swiss cheese signs are sometimes observed in cystic-solid tumors. All metastatic lesions were cystic (either unilocular or multilocular), presenting low signal on T1WI and high signal on T2WI, with no wall nodules and possible internal hemorrhagic fluid levels. The multilocular metastatic tumors demonstrated unevenly thickened partitions, also displaying honeycomb and Swiss cheese signs. Conclusion The MRI characteristics of primary and metastatic lesions in AGCT-NEL possess specific features, such as signs of hemorrhage, absence of wall nodules in the cystic portions of the tumors, and distinctive honeycomb and Swiss cheese signs, with metastatic lesions being cystic. Understanding these features can aid in improving preoperative diagnostic capabilities and reducing misdiagnosis.https://doi.org/10.1186/s12880-024-01529-5Reproductive systemOncologyOvariesAdult ovarian granulosa cell tumorMagnetic resonance imaging |
| spellingShingle | Wei Weng Yaomeng Chen Ze Liu Weiqian Chen Jiejie Hu Huihui Chen Xindian Pan Hai Wu Xinle Chi Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels BMC Medical Imaging Reproductive system Oncology Ovaries Adult ovarian granulosa cell tumor Magnetic resonance imaging |
| title | Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels |
| title_full | Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels |
| title_fullStr | Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels |
| title_full_unstemmed | Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels |
| title_short | Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels |
| title_sort | analysis of mri imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels |
| topic | Reproductive system Oncology Ovaries Adult ovarian granulosa cell tumor Magnetic resonance imaging |
| url | https://doi.org/10.1186/s12880-024-01529-5 |
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