Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload
Abstract Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. The most common treatment for thalassemia is blood transfusion which is necessary to provide the patients with healthy red blood cells containing normal hemoglobin. Repeated blood transfusion leads...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1691 |
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| author | adel abd elhaleim hagag |
| author_facet | adel abd elhaleim hagag |
| author_sort | adel abd elhaleim hagag |
| collection | DOAJ |
| description | Abstract
Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. The most common treatment for thalassemia is blood transfusion which is necessary to provide the patients with healthy red blood cells containing normal hemoglobin. Repeated blood transfusion leads to iron overload. Excess iron is deposited in body organs as liver, heart and endocrine glands causing organ damage. Iron chelation therapy is the main way to treat iron overload in beta thalassemia major. Silymarin and its biologically active component Silybin are strong antioxidant and have documented iron chelating activities in patients with beta-thalassemia major. The aim of this review was to spotlight on the therapeutic value of silymarin as iron chelator in children with beta thalassemia major with iron overload. |
| format | Article |
| id | doaj-art-883870e5389548cfa897ea660ccb25b3 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-883870e5389548cfa897ea660ccb25b32025-08-20T02:08:35ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overloadadel abd elhaleim hagag0assisstant professor of pediatrics ,tanta university egyptAbstract Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. The most common treatment for thalassemia is blood transfusion which is necessary to provide the patients with healthy red blood cells containing normal hemoglobin. Repeated blood transfusion leads to iron overload. Excess iron is deposited in body organs as liver, heart and endocrine glands causing organ damage. Iron chelation therapy is the main way to treat iron overload in beta thalassemia major. Silymarin and its biologically active component Silybin are strong antioxidant and have documented iron chelating activities in patients with beta-thalassemia major. The aim of this review was to spotlight on the therapeutic value of silymarin as iron chelator in children with beta thalassemia major with iron overload.https://mjhid.org/index.php/mjhid/article/view/1691thalassemiasilymarin |
| spellingShingle | adel abd elhaleim hagag Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload Mediterranean Journal of Hematology and Infectious Diseases thalassemia silymarin |
| title | Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload |
| title_full | Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload |
| title_fullStr | Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload |
| title_full_unstemmed | Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload |
| title_short | Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload |
| title_sort | therapeutic value of silymarin as iron chelator in children with beta thalassemia with iron overload |
| topic | thalassemia silymarin |
| url | https://mjhid.org/index.php/mjhid/article/view/1691 |
| work_keys_str_mv | AT adelabdelhaleimhagag therapeuticvalueofsilymarinasironchelatorinchildrenwithbetathalassemiawithironoverload |