ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell

ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell

BackgroundThe estrogen-estrogen receptor (ER) system plays a significant role in the sexual dimorphism of diabetic kidney disease (DKD), yet its specific effects on renal tubular injury under diabetic conditions remain incompletely characterized.MethodsHuman renal tubular (HK-2) cells were exposed t...

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Bibliographic Details
Main Authors: Dehai Yu, Ling Luo, Yu Liang, Huili Zhou, Yinghui Xiao, Xingna An, Yingzhao Wang, Zhonggao Xu, Weixia Sun, Wanning Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
diabetic kidney disease
estrogen receptor
high glucose
apoptosis
senescence
histone methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1426854/full
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