A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population
Introduction: Systemic inflammation has been associated with chronic kidney disease (CKD). In this study, we aimed to investigate a potential association between the plasma biomarker of inflammation calprotectin and new-onset CKD in a population-based cohort study. Methods: Individuals without CKD a...
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Elsevier
2024-05-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024924014815 |
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| author | Arno R. Bourgonje Martin F. Bourgonje Sacha la Bastide-van Gemert Tom Nilsen Clara Hidden Ron T. Gansevoort Douwe J. Mulder Jan-Luuk Hillebrands Stephan J.L. Bakker Robin P.F. Dullaart Harry van Goor Amaal E. Abdulle |
| author_facet | Arno R. Bourgonje Martin F. Bourgonje Sacha la Bastide-van Gemert Tom Nilsen Clara Hidden Ron T. Gansevoort Douwe J. Mulder Jan-Luuk Hillebrands Stephan J.L. Bakker Robin P.F. Dullaart Harry van Goor Amaal E. Abdulle |
| author_sort | Arno R. Bourgonje |
| collection | DOAJ |
| description | Introduction: Systemic inflammation has been associated with chronic kidney disease (CKD). In this study, we aimed to investigate a potential association between the plasma biomarker of inflammation calprotectin and new-onset CKD in a population-based cohort study. Methods: Individuals without CKD at baseline (n = 4662) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) prospective population-based cohort study in the Netherlands were included. Baseline plasma calprotectin levels were assessed in samples that had been stored at −80 °C. Occurrence of new-onset CKD was defined as a composite outcome of an estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2, urinary albumin excretion (UAE) >30 mg/24h, or both. Results: Baseline median (interquartile range) plasma calprotectin levels were 0.49 (0.35–0.68) mg/l and baseline median eGFR was 95.9 (interquartile range: 85.0–105.7) ml/min per 1.73 m2. After median follow-up of 8.3 (7.8–8.9) years, 467 participants developed new-onset CKD. Baseline plasma calprotectin levels were significantly associated with an increased risk of new-onset CKD (hazard ratio [HR] per doubling 1.28 [95% confidence interval, CI: 1.14–1.44], P < 0.001), independent of potentially confounding factors (HR 1.14 [95% CI: 1.01–1.29], P = 0.034), except for baseline high-sensitive C-reactive protein (hs-CRP) (HR 1.05 [0.91–1.21], P = 0.494). In secondary analyses, the association between plasma calprotectin and occurrence of UAE >30 mg/24h remained significant (HR 1.17 [1.02–1.34], P = 0.027), but not significantly so for the incidence of eGFR <60 ml/min per 1.73 m2 as individual outcome (HR 1.15 [0.92–1.43], P = 0.218). Conclusion: Higher plasma calprotectin levels are associated with an increased risk of developing CKD in the general population. This association is mitigated after adjustment for hs-CRP, and more pronounced with new-onset CKD defined by UAE. |
| format | Article |
| id | doaj-art-882ef4c529b340c19267435649a57cd4 |
| institution | OA Journals |
| issn | 2468-0249 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
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| series | Kidney International Reports |
| spelling | doaj-art-882ef4c529b340c19267435649a57cd42025-08-20T02:06:03ZengElsevierKidney International Reports2468-02492024-05-01951265127510.1016/j.ekir.2024.02.1392A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General PopulationArno R. Bourgonje0Martin F. Bourgonje1Sacha la Bastide-van Gemert2Tom Nilsen3Clara Hidden4Ron T. Gansevoort5Douwe J. Mulder6Jan-Luuk Hillebrands7Stephan J.L. Bakker8Robin P.F. Dullaart9Harry van Goor10Amaal E. Abdulle11Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Correspondence: Arno R. Bourgonje, Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, the Netherlands.Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsGentian AS, Moss, NorwayGentian AS, Moss, NorwayDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Internal Medicine, Division of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsIntroduction: Systemic inflammation has been associated with chronic kidney disease (CKD). In this study, we aimed to investigate a potential association between the plasma biomarker of inflammation calprotectin and new-onset CKD in a population-based cohort study. Methods: Individuals without CKD at baseline (n = 4662) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) prospective population-based cohort study in the Netherlands were included. Baseline plasma calprotectin levels were assessed in samples that had been stored at −80 °C. Occurrence of new-onset CKD was defined as a composite outcome of an estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2, urinary albumin excretion (UAE) >30 mg/24h, or both. Results: Baseline median (interquartile range) plasma calprotectin levels were 0.49 (0.35–0.68) mg/l and baseline median eGFR was 95.9 (interquartile range: 85.0–105.7) ml/min per 1.73 m2. After median follow-up of 8.3 (7.8–8.9) years, 467 participants developed new-onset CKD. Baseline plasma calprotectin levels were significantly associated with an increased risk of new-onset CKD (hazard ratio [HR] per doubling 1.28 [95% confidence interval, CI: 1.14–1.44], P < 0.001), independent of potentially confounding factors (HR 1.14 [95% CI: 1.01–1.29], P = 0.034), except for baseline high-sensitive C-reactive protein (hs-CRP) (HR 1.05 [0.91–1.21], P = 0.494). In secondary analyses, the association between plasma calprotectin and occurrence of UAE >30 mg/24h remained significant (HR 1.17 [1.02–1.34], P = 0.027), but not significantly so for the incidence of eGFR <60 ml/min per 1.73 m2 as individual outcome (HR 1.15 [0.92–1.43], P = 0.218). Conclusion: Higher plasma calprotectin levels are associated with an increased risk of developing CKD in the general population. This association is mitigated after adjustment for hs-CRP, and more pronounced with new-onset CKD defined by UAE.http://www.sciencedirect.com/science/article/pii/S2468024924014815biomarkercalprotectinchronic kidney diseaseepidemiologyinflammationpopulation science |
| spellingShingle | Arno R. Bourgonje Martin F. Bourgonje Sacha la Bastide-van Gemert Tom Nilsen Clara Hidden Ron T. Gansevoort Douwe J. Mulder Jan-Luuk Hillebrands Stephan J.L. Bakker Robin P.F. Dullaart Harry van Goor Amaal E. Abdulle A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population Kidney International Reports biomarker calprotectin chronic kidney disease epidemiology inflammation population science |
| title | A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population |
| title_full | A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population |
| title_fullStr | A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population |
| title_full_unstemmed | A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population |
| title_short | A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population |
| title_sort | prospective study of the association between plasma calprotectin levels and new onset ckd in the general population |
| topic | biomarker calprotectin chronic kidney disease epidemiology inflammation population science |
| url | http://www.sciencedirect.com/science/article/pii/S2468024924014815 |
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