Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients
ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy but are associated with immune‐mediated adverse events (imAEs), including gastrointestinal toxicities. Among these, enteritis is a less common but clinically significant complication. However, small in...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70201 |
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| author | Masayuki Orikasa Tomoyoshi Shibuya Hirotaka Ishino Masashi Omori Rina Odakura Masao Koma Kentaro Ito Takafumi Maruyama Kei Nomura Dai Ishikawa Mariko Hojo Akihito Nagahara |
| author_facet | Masayuki Orikasa Tomoyoshi Shibuya Hirotaka Ishino Masashi Omori Rina Odakura Masao Koma Kentaro Ito Takafumi Maruyama Kei Nomura Dai Ishikawa Mariko Hojo Akihito Nagahara |
| author_sort | Masayuki Orikasa |
| collection | DOAJ |
| description | ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy but are associated with immune‐mediated adverse events (imAEs), including gastrointestinal toxicities. Among these, enteritis is a less common but clinically significant complication. However, small intestinal involvement remains under‐recognized, and endoscopic findings are not well characterized. We report four cases of imAE enteritis in which small‐bowel capsule endoscopy (SBCE) was performed. SBCE revealed variable mucosal abnormalities, including villous atrophy, aphthous ulcers, and extensive erosions; in one case, deep circumferential ulcers with stricture were observed. While one patient responded to corticosteroids, the other three required escalation to biologic therapy due to steroid‐refractory disease. These findings suggest that SBCE may play a valuable role in assessing disease extent and predicting treatment responsiveness in imAE enteritis. Early utilization of SBCE could facilitate timely therapeutic decision‐making in affected patients. |
| format | Article |
| id | doaj-art-882990b398624d61a99a36296ba734b2 |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-882990b398624d61a99a36296ba734b22025-08-20T03:30:25ZengWileyJGH Open2397-90702025-06-0196n/an/a10.1002/jgh3.70201Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four PatientsMasayuki Orikasa0Tomoyoshi Shibuya1Hirotaka Ishino2Masashi Omori3Rina Odakura4Masao Koma5Kentaro Ito6Takafumi Maruyama7Kei Nomura8Dai Ishikawa9Mariko Hojo10Akihito Nagahara11Department of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanDepartment of Gastroenterology Juntendo University School of Medicine Tokyo JapanABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy but are associated with immune‐mediated adverse events (imAEs), including gastrointestinal toxicities. Among these, enteritis is a less common but clinically significant complication. However, small intestinal involvement remains under‐recognized, and endoscopic findings are not well characterized. We report four cases of imAE enteritis in which small‐bowel capsule endoscopy (SBCE) was performed. SBCE revealed variable mucosal abnormalities, including villous atrophy, aphthous ulcers, and extensive erosions; in one case, deep circumferential ulcers with stricture were observed. While one patient responded to corticosteroids, the other three required escalation to biologic therapy due to steroid‐refractory disease. These findings suggest that SBCE may play a valuable role in assessing disease extent and predicting treatment responsiveness in imAE enteritis. Early utilization of SBCE could facilitate timely therapeutic decision‐making in affected patients.https://doi.org/10.1002/jgh3.70201enterocolitisimmune‐mediated adverse eventsimmune‐related adverse eventssmall bowel endoscopy findings |
| spellingShingle | Masayuki Orikasa Tomoyoshi Shibuya Hirotaka Ishino Masashi Omori Rina Odakura Masao Koma Kentaro Ito Takafumi Maruyama Kei Nomura Dai Ishikawa Mariko Hojo Akihito Nagahara Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients JGH Open enterocolitis immune‐mediated adverse events immune‐related adverse events small bowel endoscopy findings |
| title | Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients |
| title_full | Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients |
| title_fullStr | Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients |
| title_full_unstemmed | Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients |
| title_short | Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients |
| title_sort | small bowel capsule endoscopy in immune mediated enterocolitis a case series of four patients |
| topic | enterocolitis immune‐mediated adverse events immune‐related adverse events small bowel endoscopy findings |
| url | https://doi.org/10.1002/jgh3.70201 |
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