Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study
Metabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant (n=142), preeclamptic (n=18), and healthy nonpregnant women (n=56). Preeclamptic women were selected from the same cohort....
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/8956404 |
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| author | Natalia Elvira Poveda María Fernanda Garcés Aquiles Enrique Darghan Silvia Alejandra Blanco Jaimes Estefania Pulido Sánchez Luz Amparo Díaz-Cruz Carmen Doris Garzón-Olivares Mario Orlando Parra-Pineda Alejandro Antonio Bautista-Charry Edith Ángel Müller Héctor Fabio Sandoval Alzate Luis Miguel Maldonado Acosta Elizabeth Sanchez Ariel Iván Ruíz-Parra Jorge Eduardo Caminos |
| author_facet | Natalia Elvira Poveda María Fernanda Garcés Aquiles Enrique Darghan Silvia Alejandra Blanco Jaimes Estefania Pulido Sánchez Luz Amparo Díaz-Cruz Carmen Doris Garzón-Olivares Mario Orlando Parra-Pineda Alejandro Antonio Bautista-Charry Edith Ángel Müller Héctor Fabio Sandoval Alzate Luis Miguel Maldonado Acosta Elizabeth Sanchez Ariel Iván Ruíz-Parra Jorge Eduardo Caminos |
| author_sort | Natalia Elvira Poveda |
| collection | DOAJ |
| description | Metabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant (n=142), preeclamptic (n=18), and healthy nonpregnant women (n=56). Preeclamptic women were selected from the same cohort. Pregnant women were followed during three periods of pregnancy and postpartum. The results showed a significant increase in the values of TyG and TG/HDL-c (p<0.01) as pregnancy progresses, without significant differences between healthy and preeclamptic women. TyG and TG/HDL-c indices are significantly low in nonpregnant and three months’ postpartum women when compared with each gestational period studied. TyG and TG/HDL-c indices are positively correlated with HOMA-IR in the early and middle pregnancy (p<0.05). Multiple linear regression using the TyG and TG/HDL-c indices as dependent variables showed that TyG index was significantly associated with HOMA-IR, gestational age, HDL-c, TC, LDL, fasting insulin, and mean BP (p<0.001); meanwhile, TG/HDL-c index was only associated with HOMA-IR (p<0.0242) and gestational age (p<0.001). In conclusion, the TyG and TG/HDL-c indices could be useful in monitoring insulin resistance during pregnancy. |
| format | Article |
| id | doaj-art-8825fc5167b242988fdc90b0dfd478a6 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8825fc5167b242988fdc90b0dfd478a62025-08-20T02:09:31ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/89564048956404Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal StudyNatalia Elvira Poveda0María Fernanda Garcés1Aquiles Enrique Darghan2Silvia Alejandra Blanco Jaimes3Estefania Pulido Sánchez4Luz Amparo Díaz-Cruz5Carmen Doris Garzón-Olivares6Mario Orlando Parra-Pineda7Alejandro Antonio Bautista-Charry8Edith Ángel Müller9Héctor Fabio Sandoval Alzate10Luis Miguel Maldonado Acosta11Elizabeth Sanchez12Ariel Iván Ruíz-Parra13Jorge Eduardo Caminos14Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Human Nutrition, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaEndocrine Unit-Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaDepartment of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota, ColombiaMetabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant (n=142), preeclamptic (n=18), and healthy nonpregnant women (n=56). Preeclamptic women were selected from the same cohort. Pregnant women were followed during three periods of pregnancy and postpartum. The results showed a significant increase in the values of TyG and TG/HDL-c (p<0.01) as pregnancy progresses, without significant differences between healthy and preeclamptic women. TyG and TG/HDL-c indices are significantly low in nonpregnant and three months’ postpartum women when compared with each gestational period studied. TyG and TG/HDL-c indices are positively correlated with HOMA-IR in the early and middle pregnancy (p<0.05). Multiple linear regression using the TyG and TG/HDL-c indices as dependent variables showed that TyG index was significantly associated with HOMA-IR, gestational age, HDL-c, TC, LDL, fasting insulin, and mean BP (p<0.001); meanwhile, TG/HDL-c index was only associated with HOMA-IR (p<0.0242) and gestational age (p<0.001). In conclusion, the TyG and TG/HDL-c indices could be useful in monitoring insulin resistance during pregnancy.http://dx.doi.org/10.1155/2018/8956404 |
| spellingShingle | Natalia Elvira Poveda María Fernanda Garcés Aquiles Enrique Darghan Silvia Alejandra Blanco Jaimes Estefania Pulido Sánchez Luz Amparo Díaz-Cruz Carmen Doris Garzón-Olivares Mario Orlando Parra-Pineda Alejandro Antonio Bautista-Charry Edith Ángel Müller Héctor Fabio Sandoval Alzate Luis Miguel Maldonado Acosta Elizabeth Sanchez Ariel Iván Ruíz-Parra Jorge Eduardo Caminos Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study International Journal of Endocrinology |
| title | Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study |
| title_full | Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study |
| title_fullStr | Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study |
| title_full_unstemmed | Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study |
| title_short | Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study |
| title_sort | triglycerides glucose and triglyceride high density lipoprotein cholesterol indices in normal and preeclamptic pregnancies a longitudinal study |
| url | http://dx.doi.org/10.1155/2018/8956404 |
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