Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy
Aim. To assess the relationship between fibrosis markers and structural and functional parameters in patients with various types of hypertrophic cardiomyopathy (HCM).Material and methods. This prospective comparative non-randomized study included 49 patients with HCM. Patients were divided into 3 gr...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2022-03-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3140 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849408159772311552 |
|---|---|
| author | F. M. Bogatyreva V. Yu. Kaplunova M. V. Kozhevnikova G. A. Shakaryants E. V. Privalova Yu. N. Belenkov |
| author_facet | F. M. Bogatyreva V. Yu. Kaplunova M. V. Kozhevnikova G. A. Shakaryants E. V. Privalova Yu. N. Belenkov |
| author_sort | F. M. Bogatyreva |
| collection | DOAJ |
| description | Aim. To assess the relationship between fibrosis markers and structural and functional parameters in patients with various types of hypertrophic cardiomyopathy (HCM).Material and methods. This prospective comparative non-randomized study included 49 patients with HCM. Patients were divided into 3 groups according to the disease course: group 1 — stable course (n=12; men, 8 (67%), mean age ‒ 41±12 years); group 2 — progressive course (n=26; men, men, 16 (61%). mean age — 57±11 years); group 3 — patients with atrial fibrillation (AF) (n=11; men, 4 (36%), mean age — 63±6 years). Patients underwent standard clinical and paraclinical investigations. The levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) were determined in all patients using enzyme-linked immunosorbent assay in blood serum.Results. In all patients with HCM, elevated levels of MMP-9 and TIMP-1 are noted compared to the reference values. In group 1, the MMP-9 level [Me (Q1; Q3)] was 226 (201;271) ng/ml; TIMP-1 — 410 (267;488) ng/ml; in group 2, the MMP-9 level was 236 (187;285) ng/ml; TIMP-1 — 421 (321;499) ng/ml. In the course with AF, the MMP-9 level was 260 (228;296) ng/ml, while TIMP-1 — 381,5 (305;466) ng/ml; no significant difference was revealed (p=0,59; p=0,90, respectively). A correlation was found between age and MMP-9 levels, as well as between MMP-9 levels and left atrial volume (p=0,034; p=0,035, respectively).Conclusion. The high activity of matrix metalloproteinases and their tissue inhibitors reflects enhanced fibrosis and myocardial remodeling in HCM, which is especially characteristic of patients with AF. |
| format | Article |
| id | doaj-art-88221651038545c98eec9fc4c8b2acc1 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2022-03-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-88221651038545c98eec9fc4c8b2acc12025-08-20T03:35:51Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252022-03-0121310.15829/1728-8800-2022-31402445Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathyF. M. Bogatyreva0V. Yu. Kaplunova1M. V. Kozhevnikova2G. A. Shakaryants3E. V. Privalova4Yu. N. Belenkov5I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityAim. To assess the relationship between fibrosis markers and structural and functional parameters in patients with various types of hypertrophic cardiomyopathy (HCM).Material and methods. This prospective comparative non-randomized study included 49 patients with HCM. Patients were divided into 3 groups according to the disease course: group 1 — stable course (n=12; men, 8 (67%), mean age ‒ 41±12 years); group 2 — progressive course (n=26; men, men, 16 (61%). mean age — 57±11 years); group 3 — patients with atrial fibrillation (AF) (n=11; men, 4 (36%), mean age — 63±6 years). Patients underwent standard clinical and paraclinical investigations. The levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) were determined in all patients using enzyme-linked immunosorbent assay in blood serum.Results. In all patients with HCM, elevated levels of MMP-9 and TIMP-1 are noted compared to the reference values. In group 1, the MMP-9 level [Me (Q1; Q3)] was 226 (201;271) ng/ml; TIMP-1 — 410 (267;488) ng/ml; in group 2, the MMP-9 level was 236 (187;285) ng/ml; TIMP-1 — 421 (321;499) ng/ml. In the course with AF, the MMP-9 level was 260 (228;296) ng/ml, while TIMP-1 — 381,5 (305;466) ng/ml; no significant difference was revealed (p=0,59; p=0,90, respectively). A correlation was found between age and MMP-9 levels, as well as between MMP-9 levels and left atrial volume (p=0,034; p=0,035, respectively).Conclusion. The high activity of matrix metalloproteinases and their tissue inhibitors reflects enhanced fibrosis and myocardial remodeling in HCM, which is especially characteristic of patients with AF.https://cardiovascular.elpub.ru/jour/article/view/3140hypertrophic cardiomyopathymatrix metalloproteinase-9myocardial fibrosis |
| spellingShingle | F. M. Bogatyreva V. Yu. Kaplunova M. V. Kozhevnikova G. A. Shakaryants E. V. Privalova Yu. N. Belenkov Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy Кардиоваскулярная терапия и профилактика hypertrophic cardiomyopathy matrix metalloproteinase-9 myocardial fibrosis |
| title | Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy |
| title_full | Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy |
| title_fullStr | Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy |
| title_full_unstemmed | Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy |
| title_short | Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy |
| title_sort | correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy |
| topic | hypertrophic cardiomyopathy matrix metalloproteinase-9 myocardial fibrosis |
| url | https://cardiovascular.elpub.ru/jour/article/view/3140 |
| work_keys_str_mv | AT fmbogatyreva correlationbetweenmarkersoffibrosisandmyocardialremodelinginpatientswithvariouscourseofhypertrophiccardiomyopathy AT vyukaplunova correlationbetweenmarkersoffibrosisandmyocardialremodelinginpatientswithvariouscourseofhypertrophiccardiomyopathy AT mvkozhevnikova correlationbetweenmarkersoffibrosisandmyocardialremodelinginpatientswithvariouscourseofhypertrophiccardiomyopathy AT gashakaryants correlationbetweenmarkersoffibrosisandmyocardialremodelinginpatientswithvariouscourseofhypertrophiccardiomyopathy AT evprivalova correlationbetweenmarkersoffibrosisandmyocardialremodelinginpatientswithvariouscourseofhypertrophiccardiomyopathy AT yunbelenkov correlationbetweenmarkersoffibrosisandmyocardialremodelinginpatientswithvariouscourseofhypertrophiccardiomyopathy |