The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25

The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25

Abstract Background Aberrant changes in protein phosphorylation are a hallmark of cancer, often leading to hyperactivation of signalling pathways such as the mitogen activated protein kinase (MAPK) pathway. Although kinase inhibitors are successfully used in certain clinical indications, drug resist...

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Bibliographic Details
Main Authors: Victoria Tenhaken, Ole-Morten Seternes, Ingolf Cascorbi, Henrike Bruckmueller
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
Phosphatase
MicroRNA
Cancer
DUSP2
MAPK
Online Access:https://doi.org/10.1186/s12885-025-14434-z
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