Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021.
<h4>Introduction</h4>Ovarian cancer is one of the most lethal gynecological cancers. Despite diagnosis and treatment advances, survival rates have not increased over the past 32 years. This study estimated and reported the global burden of ovarian cancer during the past 32 years to infor...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0313418 |
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| author | Brahmana Askandar Tjokroprawiro Khoirunnisa Novitasari Renata Alya Ulhaq Hanif Ardiansyah Sulistya Santi Martini |
| author_facet | Brahmana Askandar Tjokroprawiro Khoirunnisa Novitasari Renata Alya Ulhaq Hanif Ardiansyah Sulistya Santi Martini |
| author_sort | Brahmana Askandar Tjokroprawiro |
| collection | DOAJ |
| description | <h4>Introduction</h4>Ovarian cancer is one of the most lethal gynecological cancers. Despite diagnosis and treatment advances, survival rates have not increased over the past 32 years. This study estimated and reported the global burden of ovarian cancer during the past 32 years to inform preventative and control strategies.<h4>Methods</h4>We examined ovarian cancer incidence, mortality, and disability-adjusted life years (DALYs) using age-standardized rates from the Global Burden of Disease, Injuries, and Risk Factors Study 2021. high body mass index and occupational asbestos exposure were linked with death and DALYs. Data are presented as averages with 95% uncertainty intervals (UIs).<h4>Results</h4>Indonesia had 13 250 (8 574-21 565) ovarian cancer cases in 2021, with 5 296 (3 520-8958) deaths and 186 917 (121 866-309 820) DALYs. The burden increased by 233.53% for new cases, 221.95% for mortalities, and 206.65% for DALYs. The age-standardized rate also increased from 1990 to 2021. Ovarian cancer burden increased with age but declined in the 50+ year age group. According to the sociodemographic index, the gross domestic product per capita and number of obstetricians and oncologic gynecologists in provinces showed different trends.<h4>Conclusions</h4>Indonesian ovarian cancer rates are rising despite gynecologic oncologists in 24 of 34 provinces. These findings will help policymakers and healthcare providers identify ovarian cancer prevention and control gaps. |
| format | Article |
| id | doaj-art-8817bf7619ee47e58b087a7bf5cff16e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-8817bf7619ee47e58b087a7bf5cff16e2025-02-05T05:31:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031341810.1371/journal.pone.0313418Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021.Brahmana Askandar TjokroprawiroKhoirunnisa NovitasariRenata Alya UlhaqHanif Ardiansyah SulistyaSanti Martini<h4>Introduction</h4>Ovarian cancer is one of the most lethal gynecological cancers. Despite diagnosis and treatment advances, survival rates have not increased over the past 32 years. This study estimated and reported the global burden of ovarian cancer during the past 32 years to inform preventative and control strategies.<h4>Methods</h4>We examined ovarian cancer incidence, mortality, and disability-adjusted life years (DALYs) using age-standardized rates from the Global Burden of Disease, Injuries, and Risk Factors Study 2021. high body mass index and occupational asbestos exposure were linked with death and DALYs. Data are presented as averages with 95% uncertainty intervals (UIs).<h4>Results</h4>Indonesia had 13 250 (8 574-21 565) ovarian cancer cases in 2021, with 5 296 (3 520-8958) deaths and 186 917 (121 866-309 820) DALYs. The burden increased by 233.53% for new cases, 221.95% for mortalities, and 206.65% for DALYs. The age-standardized rate also increased from 1990 to 2021. Ovarian cancer burden increased with age but declined in the 50+ year age group. According to the sociodemographic index, the gross domestic product per capita and number of obstetricians and oncologic gynecologists in provinces showed different trends.<h4>Conclusions</h4>Indonesian ovarian cancer rates are rising despite gynecologic oncologists in 24 of 34 provinces. These findings will help policymakers and healthcare providers identify ovarian cancer prevention and control gaps.https://doi.org/10.1371/journal.pone.0313418 |
| spellingShingle | Brahmana Askandar Tjokroprawiro Khoirunnisa Novitasari Renata Alya Ulhaq Hanif Ardiansyah Sulistya Santi Martini Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. PLoS ONE |
| title | Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. |
| title_full | Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. |
| title_fullStr | Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. |
| title_full_unstemmed | Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. |
| title_short | Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. |
| title_sort | investigation of the trends and associated factors of ovarian cancer in indonesia a systematic analysis of the global burden of disease study 1990 2021 |
| url | https://doi.org/10.1371/journal.pone.0313418 |
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