<i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties
The <i>Vatairea</i> genus (Fabaceae family) is widespread in the Amazon rainforest. Some species of this genus are known for their ethnobotanical significance and biological potential. The present study explores the pharmacological and promising therapeutic activities, ethnobotanical pro...
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MDPI AG
2025-03-01
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| Online Access: | https://www.mdpi.com/1424-8247/18/3/422 |
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| author | Sarah Andrade Toledo Laryssa Danielle da Silva Reis Brenda Costa da Conceição Lucas Villar Pedrosa da Silva Pantoja Fábio José Coelho de Souza-Junior Flávia Cristina Santos Garcez Cristiane Socorro Ferraz Maia Eneas Andrade Fontes-Junior |
| author_facet | Sarah Andrade Toledo Laryssa Danielle da Silva Reis Brenda Costa da Conceição Lucas Villar Pedrosa da Silva Pantoja Fábio José Coelho de Souza-Junior Flávia Cristina Santos Garcez Cristiane Socorro Ferraz Maia Eneas Andrade Fontes-Junior |
| author_sort | Sarah Andrade Toledo |
| collection | DOAJ |
| description | The <i>Vatairea</i> genus (Fabaceae family) is widespread in the Amazon rainforest. Some species of this genus are known for their ethnobotanical significance and biological potential. The present study explores the pharmacological and promising therapeutic activities, ethnobotanical profile, and phytochemical prospection of <i>Vatairea</i> sp., a monophyletic group of flowering plants, which includes economically and culturally important genera due to their diverse uses, including medicinal applications. <i>V. lundellii</i>, <i>V. guianensis</i>, <i>V. erythrocarpa</i>, <i>V. fusca</i>, <i>V. heteroptera</i>, <i>V. paraensis</i>, <i>V. sericea</i>, and <i>V. macrocarpa</i> are included in the <i>Vatairea</i> sp., also recognized for its high wood quality and potential medicinal properties. Studies show significant antibacterial activity in <i>V. guianensis</i> extracts against Gram-positive and Gram-negative bacteria, whereas <i>V. macrocarpa</i> lectin exhibits broad-spectrum antibacterial effects, including modulation of antibiotic resistance. Additionally, <i>V. macrocarpa</i> and <i>V. guianensis</i> have demonstrated antifungal properties, with compounds like Vatacarpan exhibiting potent activity against <i>Candida</i> sp. In vivo studies highlight the neurotoxic effects of <i>V. macrocarpa</i> lectin, suggesting a dual role in the central nervous system. Despite these findings, research on Vatairea’s toxicological aspects is limited, with only a few studies on <i>V. macrocarpa</i> and <i>V. guianensis</i> extracts indicating a need for further exploration of this genus’ pharmacological and therapeutic potential. |
| format | Article |
| id | doaj-art-8816f676d3134e05aec1dec3483d37c8 |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-8816f676d3134e05aec1dec3483d37c82025-08-20T01:48:53ZengMDPI AGPharmaceuticals1424-82472025-03-0118342210.3390/ph18030422<i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological PropertiesSarah Andrade Toledo0Laryssa Danielle da Silva Reis1Brenda Costa da Conceição2Lucas Villar Pedrosa da Silva Pantoja3Fábio José Coelho de Souza-Junior4Flávia Cristina Santos Garcez5Cristiane Socorro Ferraz Maia6Eneas Andrade Fontes-Junior7Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém 66075110, BrazilThe <i>Vatairea</i> genus (Fabaceae family) is widespread in the Amazon rainforest. Some species of this genus are known for their ethnobotanical significance and biological potential. The present study explores the pharmacological and promising therapeutic activities, ethnobotanical profile, and phytochemical prospection of <i>Vatairea</i> sp., a monophyletic group of flowering plants, which includes economically and culturally important genera due to their diverse uses, including medicinal applications. <i>V. lundellii</i>, <i>V. guianensis</i>, <i>V. erythrocarpa</i>, <i>V. fusca</i>, <i>V. heteroptera</i>, <i>V. paraensis</i>, <i>V. sericea</i>, and <i>V. macrocarpa</i> are included in the <i>Vatairea</i> sp., also recognized for its high wood quality and potential medicinal properties. Studies show significant antibacterial activity in <i>V. guianensis</i> extracts against Gram-positive and Gram-negative bacteria, whereas <i>V. macrocarpa</i> lectin exhibits broad-spectrum antibacterial effects, including modulation of antibiotic resistance. Additionally, <i>V. macrocarpa</i> and <i>V. guianensis</i> have demonstrated antifungal properties, with compounds like Vatacarpan exhibiting potent activity against <i>Candida</i> sp. In vivo studies highlight the neurotoxic effects of <i>V. macrocarpa</i> lectin, suggesting a dual role in the central nervous system. Despite these findings, research on Vatairea’s toxicological aspects is limited, with only a few studies on <i>V. macrocarpa</i> and <i>V. guianensis</i> extracts indicating a need for further exploration of this genus’ pharmacological and therapeutic potential.https://www.mdpi.com/1424-8247/18/3/422<i>Vatairea</i> sp.folk medicinephytochemicalpharmacologyethnobotany |
| spellingShingle | Sarah Andrade Toledo Laryssa Danielle da Silva Reis Brenda Costa da Conceição Lucas Villar Pedrosa da Silva Pantoja Fábio José Coelho de Souza-Junior Flávia Cristina Santos Garcez Cristiane Socorro Ferraz Maia Eneas Andrade Fontes-Junior <i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties Pharmaceuticals <i>Vatairea</i> sp. folk medicine phytochemical pharmacology ethnobotany |
| title | <i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties |
| title_full | <i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties |
| title_fullStr | <i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties |
| title_full_unstemmed | <i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties |
| title_short | <i>Vatairea</i> Genus as a Potential Therapeutic Agent—A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties |
| title_sort | i vatairea i genus as a potential therapeutic agent a comprehensive review of ethnobotanical phytochemical and pharmacological properties |
| topic | <i>Vatairea</i> sp. folk medicine phytochemical pharmacology ethnobotany |
| url | https://www.mdpi.com/1424-8247/18/3/422 |
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