Differential effects of fine particulate matter constituents on acute coronary syndrome onset
Abstract Fine particulate matter has been linked with acute coronary syndrome. Nevertheless, the key constituents remain unclear. Here, we conduct a nationwide case-crossover study in China during 2015–2021 to quantify the associations between fine particulate matter constituents (organic matter, bl...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55080-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559296121241600 |
|---|---|
| author | Yixuan Jiang Chuyuan Du Renjie Chen Jialu Hu Xinlei Zhu Xiaowei Xue Qinglin He Jun Lu Junbo Ge Yong Huo Haidong Kan |
| author_facet | Yixuan Jiang Chuyuan Du Renjie Chen Jialu Hu Xinlei Zhu Xiaowei Xue Qinglin He Jun Lu Junbo Ge Yong Huo Haidong Kan |
| author_sort | Yixuan Jiang |
| collection | DOAJ |
| description | Abstract Fine particulate matter has been linked with acute coronary syndrome. Nevertheless, the key constituents remain unclear. Here, we conduct a nationwide case-crossover study in China during 2015–2021 to quantify the associations between fine particulate matter constituents (organic matter, black carbon, nitrate, sulfate, and ammonium) and acute coronary syndrome, and to identify the critical contributors. Our findings reveal all five constituents are significantly associated with acute coronary syndrome onset. The magnitude of associations peaks on the concurrent day, attenuates thereafter, and becomes null at lag 2 day. The largest effects are observed for organic matter and black carbon, with each interquartile range increase in their concentrations corresponding to 2.15% and 2.03% increases in acute coronary syndrome onset, respectively. These two components also contribute most to the joint effects, accounting for 31% and 22%, respectively. Our findings highlight tailored clinical management and targeted control of carbonaceous components to protect cardiovascular health. |
| format | Article |
| id | doaj-art-8810392b0a564dfc9098fb66e2ec5b2f |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-8810392b0a564dfc9098fb66e2ec5b2f2025-01-05T12:36:52ZengNature PortfolioNature Communications2041-17232024-12-0115111010.1038/s41467-024-55080-6Differential effects of fine particulate matter constituents on acute coronary syndrome onsetYixuan Jiang0Chuyuan Du1Renjie Chen2Jialu Hu3Xinlei Zhu4Xiaowei Xue5Qinglin He6Jun Lu7Junbo Ge8Yong Huo9Haidong Kan10School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversityDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversityDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Peking University First HospitalSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan UniversityAbstract Fine particulate matter has been linked with acute coronary syndrome. Nevertheless, the key constituents remain unclear. Here, we conduct a nationwide case-crossover study in China during 2015–2021 to quantify the associations between fine particulate matter constituents (organic matter, black carbon, nitrate, sulfate, and ammonium) and acute coronary syndrome, and to identify the critical contributors. Our findings reveal all five constituents are significantly associated with acute coronary syndrome onset. The magnitude of associations peaks on the concurrent day, attenuates thereafter, and becomes null at lag 2 day. The largest effects are observed for organic matter and black carbon, with each interquartile range increase in their concentrations corresponding to 2.15% and 2.03% increases in acute coronary syndrome onset, respectively. These two components also contribute most to the joint effects, accounting for 31% and 22%, respectively. Our findings highlight tailored clinical management and targeted control of carbonaceous components to protect cardiovascular health.https://doi.org/10.1038/s41467-024-55080-6 |
| spellingShingle | Yixuan Jiang Chuyuan Du Renjie Chen Jialu Hu Xinlei Zhu Xiaowei Xue Qinglin He Jun Lu Junbo Ge Yong Huo Haidong Kan Differential effects of fine particulate matter constituents on acute coronary syndrome onset Nature Communications |
| title | Differential effects of fine particulate matter constituents on acute coronary syndrome onset |
| title_full | Differential effects of fine particulate matter constituents on acute coronary syndrome onset |
| title_fullStr | Differential effects of fine particulate matter constituents on acute coronary syndrome onset |
| title_full_unstemmed | Differential effects of fine particulate matter constituents on acute coronary syndrome onset |
| title_short | Differential effects of fine particulate matter constituents on acute coronary syndrome onset |
| title_sort | differential effects of fine particulate matter constituents on acute coronary syndrome onset |
| url | https://doi.org/10.1038/s41467-024-55080-6 |
| work_keys_str_mv | AT yixuanjiang differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT chuyuandu differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT renjiechen differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT jialuhu differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT xinleizhu differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT xiaoweixue differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT qinglinhe differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT junlu differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT junboge differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT yonghuo differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset AT haidongkan differentialeffectsoffineparticulatematterconstituentsonacutecoronarysyndromeonset |