Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers

Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers

Background & Aims: Acute liver failure (ALF) is defined as rapid onset coagulopathy and encephalopathy in patients without a prior history of liver disease. We performed untargeted and targeted serum proteomics to delineate processes occurring in adult patients with ALF and to identify poten...

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Main Authors: Katharina Remih, Franziska-Maria Hufnagel, Anna Sophie Karl, Valerie Durkalski-Mauldin, William Martens Lee, Constantine J. Karvellas, Zemin Su, Jody A. Rule, Petra Tomanová, Laura Krieg, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Frank Tacke, Sonja Luckhardt, Nicole Ziegler, Aimo Kannt, Bastian Engel, Richard Taubert, Robert John Fontana, Pavel Strnad
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:JHEP Reports
Subjects:
Acute liver injury
Proteomic profiling
Acetaminophen
ALF subtyping
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592500014X
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