GLUT1 inhibition by BAY-876 induces metabolic changes and cell death in human colorectal cancer cells

GLUT1 inhibition by BAY-876 induces metabolic changes and cell death in human colorectal cancer cells

Abstract Background Glucose transporter 1 (GLUT1) is known to play a crucial role in glucose uptake in malignant tumors. GLUT1 inhibitors reportedly exhibit anti-tumor effects by suppressing cancer cell proliferation. BAY-876, a selective GLUT1 inhibitor, has been shown to inhibit tumor growth in ov...

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Main Authors: Masato Hayashi, Keishi Nakamura, Shinichi Harada, Mariko Tanaka, Akiko Kobayashi, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Jun Kinoshita, Noriyuki Inaki
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Glucose transporter 1
BAY-876
Apoptosis
Online Access:https://doi.org/10.1186/s12885-025-14141-9
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https://doi.org/10.1186/s12885-025-14141-9

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