Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease
Background: Diabetic kidney disease (DKD) is a global health issue. Epigenetic changes play an important role in the pathogenesis of this disease. Summary: DKD is currently the leading cause of kidney failure worldwide. Although much is known about the pathophysiology of DKD, the research...
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Karger Publishers
2024-11-01
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| Series: | Glomerular Diseases |
| Online Access: | https://karger.com/doi/10.1159/000541923 |
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| author | Marita Liebisch Gunter Wolf |
| author_facet | Marita Liebisch Gunter Wolf |
| author_sort | Marita Liebisch |
| collection | DOAJ |
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Background: Diabetic kidney disease (DKD) is a global health issue. Epigenetic changes play an important role in the pathogenesis of this disease. Summary: DKD is currently the leading cause of kidney failure worldwide. Although much is known about the pathophysiology of DKD, the research field of epigenetics is relatively new. Several recent studies have demonstrated that diabetes-induced dysregulation of epigenetic mechanisms alters the expression of pathological genes in kidney cells. If these changes persist for a long time, the so-called “metabolic memory” could be established. In this review, we highlight diabetes-induced epigenetic modifications associated with DKD. While there is a substantial amount of literature on epigenetic changes, only a few studies describe the underlying molecular mechanisms. Detailed analyses have shown that epigenetic changes play an important role in known pathological features of DKD, such as podocyte injury, fibrosis, accumulation of extracellular matrix, or oxidative injury, all of which contribute to the pathophysiology of disease. The transforming growth factor-β plays a key role as it is involved in all-mentioned epigenetic types of regulation. Key Messages: Epigenetic is crucial for the development and progression of DKD, but the detailed molecular mechanisms have to be further analyzed more in detail. Background: Diabetic kidney disease (DKD) is a global health issue. Epigenetic changes play an important role in the pathogenesis of this disease. Summary: DKD is currently the leading cause of kidney failure worldwide. Although much is known about the pathophysiology of DKD, the research field of epigenetics is relatively new. Several recent studies have demonstrated that diabetes-induced dysregulation of epigenetic mechanisms alters the expression of pathological genes in kidney cells. If these changes persist for a long time, the so-called “metabolic memory” could be established. In this review, we highlight diabetes-induced epigenetic modifications associated with DKD. While there is a substantial amount of literature on epigenetic changes, only a few studies describe the underlying molecular mechanisms. Detailed analyses have shown that epigenetic changes play an important role in known pathological features of DKD, such as podocyte injury, fibrosis, accumulation of extracellular matrix, or oxidative injury, all of which contribute to the pathophysiology of disease. The transforming growth factor-β plays a key role as it is involved in all-mentioned epigenetic types of regulation. Key Messages: Epigenetic is crucial for the development and progression of DKD, but the detailed molecular mechanisms have to be further analyzed more in detail. |
| format | Article |
| id | doaj-art-87ff4423bae2437da1ea3b472590faeb |
| institution | OA Journals |
| issn | 2673-3633 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Glomerular Diseases |
| spelling | doaj-art-87ff4423bae2437da1ea3b472590faeb2025-08-20T02:31:54ZengKarger PublishersGlomerular Diseases2673-36332024-11-014121122610.1159/000541923541923Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney DiseaseMarita LiebischGunter Wolfhttps://orcid.org/0000-0002-3291-0610 Background: Diabetic kidney disease (DKD) is a global health issue. Epigenetic changes play an important role in the pathogenesis of this disease. Summary: DKD is currently the leading cause of kidney failure worldwide. Although much is known about the pathophysiology of DKD, the research field of epigenetics is relatively new. Several recent studies have demonstrated that diabetes-induced dysregulation of epigenetic mechanisms alters the expression of pathological genes in kidney cells. If these changes persist for a long time, the so-called “metabolic memory” could be established. In this review, we highlight diabetes-induced epigenetic modifications associated with DKD. While there is a substantial amount of literature on epigenetic changes, only a few studies describe the underlying molecular mechanisms. Detailed analyses have shown that epigenetic changes play an important role in known pathological features of DKD, such as podocyte injury, fibrosis, accumulation of extracellular matrix, or oxidative injury, all of which contribute to the pathophysiology of disease. The transforming growth factor-β plays a key role as it is involved in all-mentioned epigenetic types of regulation. Key Messages: Epigenetic is crucial for the development and progression of DKD, but the detailed molecular mechanisms have to be further analyzed more in detail. Background: Diabetic kidney disease (DKD) is a global health issue. Epigenetic changes play an important role in the pathogenesis of this disease. Summary: DKD is currently the leading cause of kidney failure worldwide. Although much is known about the pathophysiology of DKD, the research field of epigenetics is relatively new. Several recent studies have demonstrated that diabetes-induced dysregulation of epigenetic mechanisms alters the expression of pathological genes in kidney cells. If these changes persist for a long time, the so-called “metabolic memory” could be established. In this review, we highlight diabetes-induced epigenetic modifications associated with DKD. While there is a substantial amount of literature on epigenetic changes, only a few studies describe the underlying molecular mechanisms. Detailed analyses have shown that epigenetic changes play an important role in known pathological features of DKD, such as podocyte injury, fibrosis, accumulation of extracellular matrix, or oxidative injury, all of which contribute to the pathophysiology of disease. The transforming growth factor-β plays a key role as it is involved in all-mentioned epigenetic types of regulation. Key Messages: Epigenetic is crucial for the development and progression of DKD, but the detailed molecular mechanisms have to be further analyzed more in detail. https://karger.com/doi/10.1159/000541923 |
| spellingShingle | Marita Liebisch Gunter Wolf Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease Glomerular Diseases |
| title | Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease |
| title_full | Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease |
| title_fullStr | Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease |
| title_full_unstemmed | Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease |
| title_short | Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease |
| title_sort | role of epigenetic changes in the pathophysiology of diabetic kidney disease |
| url | https://karger.com/doi/10.1159/000541923 |
| work_keys_str_mv | AT maritaliebisch roleofepigeneticchangesinthepathophysiologyofdiabetickidneydisease AT gunterwolf roleofepigeneticchangesinthepathophysiologyofdiabetickidneydisease |