Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

<h4>Background</h4>Liquid biopsies enable the detection of circulating tumor DNA (ctDNA). However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential.<h4>Methods and findings</h4>...

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Bibliographic Details
Main Authors:	Fumiaki Watanabe, Koichi Suzuki, Sawako Tamaki, Iku Abe, Yuhei Endo, Yuji Takayama, Hideki Ishikawa, Nao Kakizawa, Masaaki Saito, Kazushige Futsuhara, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-01-01
Series:	PLoS ONE
Online Access:	https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0227366/1/pone.0227366.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T105309Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

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