Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

A potent class of HIV-1 broadly neutralizing antibodies (bnAbs) targets the envelope glycoprotein’s membrane proximal exposed region (MPER) through a proposed mechanism where hypervariable loops embed into lipid bilayers and engage headgroup moieties alongside the epitope. We address the feasibility...

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Bibliographic Details
Main Authors: Colleen A Maillie, Kiana Golden, Ian A Wilson, Andrew B Ward, Marco Mravic
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
molecular dynamics
lipid membranes
broadly neutralizing antibodies
HIV
MPER
Online Access:https://elifesciences.org/articles/90139
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