Rhus coriaria (Sumac) induces autophagic cell death and inhibits mTOR, p38MAPK and STAT3 pathways in 5fluorouracil-resistant colorectal cancer cells

Rhus coriaria (Sumac) induces autophagic cell death and inhibits mTOR, p38MAPK and STAT3 pathways in 5fluorouracil-resistant colorectal cancer cells

IntroductionColorectal cancer is a leading cause of cancer related-death worldwide, and resistance to 5-fluorouracil (5FU, a key component of chemotherapy regimens, is a major clinical concern. We have previously elucidated the effects of Rhus coriaria ethanolic extract (RCE) in triple-negative brea...

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Main Authors: Zohra Nausheen Nizami, Mazoun Al Azzani, Samah Khaldi, Adil Farooq Wali, Rym Magramane, Shamaa Abdul Samad, Ali H. Eid, Kholoud Arafat, Yusra Al Dhaheri, Samir Attoub, Rabah Iratni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
5-fluorouracil
chemoresistance
colorectal cancer
apoptosis
autophagy
Survivin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1542204/full
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