Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments
Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM mode...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/924045 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850213322184458240 |
|---|---|
| author | Åsa Håkansson Camilla Bränning Göran Molin Diya Adawi Marie-Louise Hagslätt Margareta Nyman Bengt Jeppsson Siv Ahrné |
| author_facet | Åsa Håkansson Camilla Bränning Göran Molin Diya Adawi Marie-Louise Hagslätt Margareta Nyman Bengt Jeppsson Siv Ahrné |
| author_sort | Åsa Håkansson |
| collection | DOAJ |
| description | Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators. |
| format | Article |
| id | doaj-art-87e8f3d12451476fa8b1cefbdccc98e1 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-87e8f3d12451476fa8b1cefbdccc98e12025-08-20T02:09:09ZengWileyGastroenterology Research and Practice1687-61211687-630X2011-01-01201110.1155/2011/924045924045Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS TreatmentsÅsa Håkansson0Camilla Bränning1Göran Molin2Diya Adawi3Marie-Louise Hagslätt4Margareta Nyman5Bengt Jeppsson6Siv Ahrné7Food Hygiene, Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, SwedenDivision of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, SwedenFood Hygiene, Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, SwedenDepartment of Surgery, Skåne University Hospital, Lund University, 205 02 Malmö, SwedenFood Hygiene, Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, SwedenDivision of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, SwedenDepartment of Surgery, Skåne University Hospital, Lund University, 205 02 Malmö, SwedenFood Hygiene, Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, SwedenInflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.http://dx.doi.org/10.1155/2011/924045 |
| spellingShingle | Åsa Håkansson Camilla Bränning Göran Molin Diya Adawi Marie-Louise Hagslätt Margareta Nyman Bengt Jeppsson Siv Ahrné Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments Gastroenterology Research and Practice |
| title | Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments |
| title_full | Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments |
| title_fullStr | Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments |
| title_full_unstemmed | Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments |
| title_short | Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments |
| title_sort | colorectal oncogenesis and inflammation in a rat model based on chronic inflammation due to cycling dss treatments |
| url | http://dx.doi.org/10.1155/2011/924045 |
| work_keys_str_mv | AT asahakansson colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT camillabranning colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT goranmolin colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT diyaadawi colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT marielouisehagslatt colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT margaretanyman colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT bengtjeppsson colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments AT sivahrne colorectaloncogenesisandinflammationinaratmodelbasedonchronicinflammationduetocyclingdsstreatments |