Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops
In this study, the antifungal potential of chemical constituents of <i>Piper ceanothifolium</i> Kunth was determined against three phytopathogenic fungi associated with the cocoa crop. The methodology included the phytochemical study of the inflorescences of <i>P. ceanothifolium<...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/14/6/934 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850280442966573056 |
|---|---|
| author | Yudy S. Mahecha-Jimenez Oscar J. Patiño-Ladino Juliet A. Prieto-Rodríguez |
| author_facet | Yudy S. Mahecha-Jimenez Oscar J. Patiño-Ladino Juliet A. Prieto-Rodríguez |
| author_sort | Yudy S. Mahecha-Jimenez |
| collection | DOAJ |
| description | In this study, the antifungal potential of chemical constituents of <i>Piper ceanothifolium</i> Kunth was determined against three phytopathogenic fungi associated with the cocoa crop. The methodology included the phytochemical study of the inflorescences of <i>P. ceanothifolium</i>, the synthesis of a chroman-4-one type derivative and the evaluation of the antifungal activity against <i>Moniliophthora roreri</i>, <i>Fusarium solani</i>, and <i>Lasiodiplodia theobromae</i>. The phytochemical study led to the isolation and identification of two new hydroquinones (<b>1</b> and <b>5</b>), together with three known compounds (hydroquinones <b>2</b> and <b>3,</b> and chromene <b>4</b>). The synthesis of a new chromone <b>6</b> obtained from <b>2</b> through an oxa-Michael type intramolecular cyclization is also reported. All compounds showed strong antifungal activity, with <b>6</b> (IC<sub>50</sub> of 16.9 µM) standing out for its action against <i>F. solani</i>, while prenylated hydroquinones <b>1</b> (30.4 µM) and <b>2</b> (60.0 µM) were the most active against <i>M. roreri</i> and <i>L. theobromae</i>, respectively. The results of this research represent the first report of the chemical composition and antifungal properties for <i>P. ceanotifolium</i>, suggesting its potential use as a control method against <i>M. roreri</i>, <i>F. solani</i>, and <i>L. theobromae</i>. |
| format | Article |
| id | doaj-art-87e6f711c0dc412da29d8e922155a24c |
| institution | OA Journals |
| issn | 2223-7747 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-87e6f711c0dc412da29d8e922155a24c2025-08-20T01:48:45ZengMDPI AGPlants2223-77472025-03-0114693410.3390/plants14060934Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa CropsYudy S. Mahecha-Jimenez0Oscar J. Patiño-Ladino1Juliet A. Prieto-Rodríguez2Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia (UNAL), Sede Bogotá, Bogotá 111711, ColombiaDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia (UNAL), Sede Bogotá, Bogotá 111711, ColombiaDepartamento de Química, Facultad de Ciencias, Pontificia Universidad Javeriana (PUJ), Sede Bogotá, Bogotá 110231, ColombiaIn this study, the antifungal potential of chemical constituents of <i>Piper ceanothifolium</i> Kunth was determined against three phytopathogenic fungi associated with the cocoa crop. The methodology included the phytochemical study of the inflorescences of <i>P. ceanothifolium</i>, the synthesis of a chroman-4-one type derivative and the evaluation of the antifungal activity against <i>Moniliophthora roreri</i>, <i>Fusarium solani</i>, and <i>Lasiodiplodia theobromae</i>. The phytochemical study led to the isolation and identification of two new hydroquinones (<b>1</b> and <b>5</b>), together with three known compounds (hydroquinones <b>2</b> and <b>3,</b> and chromene <b>4</b>). The synthesis of a new chromone <b>6</b> obtained from <b>2</b> through an oxa-Michael type intramolecular cyclization is also reported. All compounds showed strong antifungal activity, with <b>6</b> (IC<sub>50</sub> of 16.9 µM) standing out for its action against <i>F. solani</i>, while prenylated hydroquinones <b>1</b> (30.4 µM) and <b>2</b> (60.0 µM) were the most active against <i>M. roreri</i> and <i>L. theobromae</i>, respectively. The results of this research represent the first report of the chemical composition and antifungal properties for <i>P. ceanotifolium</i>, suggesting its potential use as a control method against <i>M. roreri</i>, <i>F. solani</i>, and <i>L. theobromae</i>.https://www.mdpi.com/2223-7747/14/6/934<i>Piper ceanothifolium</i><i>Theobroma cacao</i><i>Moniliophtora roreri</i><i>Lasiodiplodia theobromae</i><i>Fusarium solani</i>prenylated hydroquinones |
| spellingShingle | Yudy S. Mahecha-Jimenez Oscar J. Patiño-Ladino Juliet A. Prieto-Rodríguez Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops Plants <i>Piper ceanothifolium</i> <i>Theobroma cacao</i> <i>Moniliophtora roreri</i> <i>Lasiodiplodia theobromae</i> <i>Fusarium solani</i> prenylated hydroquinones |
| title | Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops |
| title_full | Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops |
| title_fullStr | Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops |
| title_full_unstemmed | Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops |
| title_short | Chemical Constituents and Antifungal Properties of <i>Piper ceanothifolium</i> Kunth Against Phytopathogens Associated with Cocoa Crops |
| title_sort | chemical constituents and antifungal properties of i piper ceanothifolium i kunth against phytopathogens associated with cocoa crops |
| topic | <i>Piper ceanothifolium</i> <i>Theobroma cacao</i> <i>Moniliophtora roreri</i> <i>Lasiodiplodia theobromae</i> <i>Fusarium solani</i> prenylated hydroquinones |
| url | https://www.mdpi.com/2223-7747/14/6/934 |
| work_keys_str_mv | AT yudysmahechajimenez chemicalconstituentsandantifungalpropertiesofipiperceanothifoliumikunthagainstphytopathogensassociatedwithcocoacrops AT oscarjpatinoladino chemicalconstituentsandantifungalpropertiesofipiperceanothifoliumikunthagainstphytopathogensassociatedwithcocoacrops AT julietaprietorodriguez chemicalconstituentsandantifungalpropertiesofipiperceanothifoliumikunthagainstphytopathogensassociatedwithcocoacrops |